Evidence map›Paper›PMID 39683769›Full record

ArticleMolecules (Basel, Switzerland)2024

Pimozide and Adipic Acid: A New Multicomponent Crystalline Entity for Improved Pharmaceutical Behavior.

Alessandra Buscarini, Michael J Zaworotko, Catiúcia R M O Matos, Fabrizia Grepioni, Laura Contini, Doretta Capsoni, Valeria Friuli, Lauretta Maggi, Giovanna Bruni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Co-amorphization for solubility and dissolution rate improvement: the case of low-crystallization-tendency drugs.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessandra BuscariniDepartment of Chemistry, Physical Chemistry Section & C.S.G.I. (Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase), University of Pavia, Via Taramelli 16, 27100 Pavia, Italy.ORCID 0009-0004-8561-7831
Michael J ZaworotkoDepartment of Chemical Sciences and Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland.ORCID 0000-0002-1360-540X
Catiúcia R M O MatosDepartment of Chemical Sciences and Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland.ORCID 0000-0001-8355-396X
Fabrizia GrepioniDipartimento di Chimica "Giacomo Ciamician", Università di Bologna, Via Selmi 2, 40126 Bologna, Italy.
Laura ContiniDipartimento di Chimica "Giacomo Ciamician", Università di Bologna, Via Selmi 2, 40126 Bologna, Italy.ORCID 0000-0001-5156-0903
Doretta CapsoniDepartment of Chemistry, Physical Chemistry Section & C.S.G.I. (Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase), University of Pavia, Via Taramelli 16, 27100 Pavia, Italy.ORCID 0000-0002-1064-7196
Valeria FriuliDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-2975-4362
Lauretta MaggiDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-1408-8846
Giovanna BruniDepartment of Chemistry, Physical Chemistry Section & C.S.G.I. (Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase), University of Pavia, Via Taramelli 16, 27100 Pavia, Italy.ORCID 0000-0003-1958-2998

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pimozide is a first-generation antipsychotic used in the treatment of schizophrenia, Gilles de la Tourette syndrome, and other chronic psychoses. Its in vivo efficacy is limited by poor solubility and consequent poor bioavailability. Therefore, adipic acid was used as a coformer for the preparation of a binary product with improved pharmaceutical properties. The thermal behavior of the liquid-assisted grinding products of compositions included in the range 0.1 <

Indexed as

AdipatesPimozideSolubilityX-Ray DiffractionAntipsychotic AgentsChemistry, PharmaceuticalCrystallizationTabletsWettabilityAdipatesadipic acidAntipsychotic AgentsPimozideTabletsadipic acidbiopharmaceutics classification system’s class IIDifferential Scanning Calorimetrypharmaceutical saltspimozidepowder X-ray diffractionsingle crystal X-ray diffractionsolubility

Identifiers

PMID39683769
PMCPMC11643450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.