Evidence map›Paper›PMID 39683653›Full record

ArticleMolecules (Basel, Switzerland)2024

Structure-Activity Relationship Studies in a Series of 2-Aryloxy-

Nigam M Mishra, Brittany D Spitznagel, Yu Du, Yasmeen K Mohamed, Ying Qin, C David Weaver, Kyle A Emmitte

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nigam M MishraDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0003-2695-6695
Brittany D SpitznagelDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0003-4172-4147
Yu DuDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Yasmeen K MohamedDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0009-0005-3623-6335
Ying QinDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
C David WeaverDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Kyle A EmmitteDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0002-6643-3947

Funding

Slack Potassium Channel Inhibitors for the Treatment of Childhood EpilepsiesR33NS109521 · NINDS · VANDERBILT UNIVERSITY · PI EMMITTE, KYLE A, WEAVER, C DAVID · 2020 to 2021
$787k
Fluorescent and Luminescent Kinetic Imaging Plate ReaderS10OD021734 · OD · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG · 2016 to 2016
$671k
NIH HHS 5R33NS109521-03NIH HHS 5R33NS109521-03A1NIH HHS S10 OD021734NINDS NIH HHS R33 NS109521
6 · The paper itself

Abstract

Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare, serious, and pharmacoresistant epileptic disorder often linked to gain-of-function mutations in the

Indexed as

AcetamidesPotassium Channel BlockersAnimalsHumansMiceNerve Tissue ProteinsPatch-Clamp TechniquesPotassium Channels, Sodium-ActivatedPyrimidinesStructure-Activity RelationshipAcetamidesKCNT1 protein, humanNerve Tissue ProteinsPotassium Channel BlockersPotassium Channels, Sodium-ActivatedPyrimidinesCNSEIMFSepilepsyKCNT1KNa1.1MMPSIpyrimidineSLACKSlo2.2

Identifiers

PMID39683653
PMCPMC11643494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.