Evidence map›Paper›PMID 39683603›Full record

ArticleNutrients2024

Optimization and Chemical Characterization of Extracts Obtained from

Pouya Mohammadnezhad, Alberto Valdés, Alejandro Cifuentes

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Molecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. Phytochemical Profiling ofMolecules (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Evaluation of the In Vitro Blood-Brain Barrier Transport ofInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pouya MohammadnezhadFoodomics Laboratory, Instituto de Investigacion en Ciencias de la Alimentacion (CIAL), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Nicolas Cabrera 9, 28049 Madrid, Spain.ORCID 0009-0004-8838-3225
Alberto ValdésFoodomics Laboratory, Instituto de Investigacion en Ciencias de la Alimentacion (CIAL), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Nicolas Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0002-7901-5816
Alejandro CifuentesFoodomics Laboratory, Instituto de Investigacion en Ciencias de la Alimentacion (CIAL), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Nicolas Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0002-7464-0217

Funding

Ministry of Science and Innovation of Spain PID2020-113050RB-I00
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe genus

methodsIn this work, a pressurized liquid extraction (PLE) method was optimized to extract

resultsThe results indicated that EtAc and CPME were the best solvents to be used, with the results obtained from the aerial parts being better than those obtained from the root samples. Thereafter, the PLE method was further optimized by combining these solvents in different percentages (100% EtAc, 100% CPME, and 50:50% (

conclusionsThe results obtained together with the application of advanced statistical analysis and molecular docking simulations suggested several sesquiterpenoids, such as selina-3,7(11)-diene, guaiol acetate, α-cyperone, and farnesyl acetate, as the molecules responsible of the in vitro results observed, with good neuroprotective potential against AD.

Indexed as

Cholinesterase InhibitorsFerulaNeuroprotective AgentsPlant Components, AerialPlant ExtractsPlant RootsAcetylcholinesteraseAntioxidantsButyrylcholinesteraseMolecular Docking SimulationPhenolsSolventsAcetylcholinesteraseAntioxidantsButyrylcholinesteraseCholinesterase InhibitorsNeuroprotective AgentsPhenolsPlant ExtractsSolventsgreen extractionHPLC/GC-MSmolecular dockingneuroprotectionpressurized liquid extractionsesquiterpenoids

Identifiers

PMID39683603
PMCPMC11644649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.