ArticleNutrients2024
Mediation Effect of Oxidative Stress on Association Between Selenium Intake and Cognition in American Adults.
Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Association Between Cardiometabolic Index and Liver Fibrosis: Mediation Analysis of Oxidative Stress Factors.Anatolian journal of cardiology · 2026Article
- Association of central adiposity indices with cognitive impairment in elderly populations: Development and validation of a risk prediction nomogram using NHANES and CHARLS cohorts.Journal of Alzheimer's disease : JAD · 2026Article
- Towards Precision and Balance in Selenium Nutrition: From Innovation to Application.Nutrients · 2026Article
- Gut microbiota, nutrients, and depression.Frontiers in nutrition · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectivesDementia affects millions of aged people globally and mainly results from oxidative stress. Selenium shows beneficial effects on dementia however it remains elusive for the mediation effect of oxidative stress on the association between selenium and cognition. The present study firstly investigated the potential mediation role of oxidative stress on the relationship of selenium and cognition.
methodsA total of 2154 adults aged 60 years and older from the National Health and Nutrition Examination Survey 2011-2014 were selected for the study. Weighted multivariate linear regression, weighted logistic regression, and mediation effect analysis were employed to investigate the association among selenium intake, cognition, and oxidative stress.
resultsSelenium intake was positively associated with cognition, albumin, and vitamin D, negatively associated with uric acid, and exhibited no correlation with gamma glutamyl transpeptidase (GGT). Cognition was positively correlated with albumin and vitamin D, negatively related to GGT, and had no association with uric acid. Albumin and vitamin D significantly mediated the relationship between selenium intake and cognition, and the mediation proportion values of albumin and vitamin D were 3.85% and 8.02%, respectively.
conclusionsFor the first time, our findings demonstrated that higher selenium intake decreased cognitive impairment and oxidative stress levels. Moreover, the relationship between selenium intake and cognition was mediated by oxidative stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.