ArticleNutrients2024
Synergistic Effects of Chitosan and Fish Oil on Lipid Metabolism in Rats Fed a High-Fat and Low-Carbohydrate Diet.
Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Fish oil rich in ω-3 fatty acid alleviates long-term high fructose consumption-induced fatty liver and kidney dysfunction in rats.Journal of food and drug analysis · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
BACKGROUND/
objectivesAlthough high-fat, low-carbohydrate diets are used for weight loss and type 2 diabetes management, their high-fat content may have negative effects. This study examines the effects of replacing cellulose with chitosan and part of the fat with fish oil in a high-fat, low-carbohydrate diet on lipid metabolism in rats.
methodsThe experiment involved 35 six-week-old male SD rats, divided into five groups: normal control diet (ND), high-fat diet (HF), high-fat, low-carbohydrate diet (LC), LC with 5% chitosan (LC-CH), and LC with 5% chitosan and 5% fish oil (LC-CHF).
resultsAfter 15 weeks, the HF group had the highest liver weight, and the LC group had the highest adipose tissue weight. The LC-CHF group showed significantly reduced body, liver, and adipose tissue weights, lower ALT, AST, TNF-α, and cholesterol levels, as well as improved liver enzyme activity and fat synthesis regulation. LC-CHF also promoted fat breakdown in adipose tissue, reducing adipocyte size.
conclusionsOur findings suggest the modified high-fat, low-carbohydrate diet with chitosan and fish oil improved obesity and fatty liver outcomes compared to a standard high-fat diet.
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