Visualization of Stress Fiber Formation Induced by Photodynamic Therapy with Porphylipoprotein.

Atsushi Taninaka, Hiromi Kurokawa, Mayuka Kamiyanagi, Osamu Takeuchi, Hirofumi Matsui, Hidemi Shigekawa

Abstract read

In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Atsushi TaninakaInstitute of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8573, Japan.

Hiromi KurokawaFaculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.

Mayuka KamiyanagiInstitute of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8573, Japan.

Osamu TakeuchiInstitute of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8573, Japan.

Hirofumi MatsuiFaculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.ORCID 0000-0002-7659-5093

Hidemi ShigekawaInstitute of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8573, Japan.ORCID 0000-0001-9550-5148

Funding

Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science, and Japan Core Research Evolutional Science and Technology (CREST) 23H00264, and JPMJCR1875

6 · The paper itself

Abstract

We investigated stress fiber formation induced by photodynamic therapy (PDT) with porphylipoprotein (PLP) by observing actin filaments by super-resolution confocal microscopy and measuring the cellular elastic modulus by atomic force microscopy. We identified different intracellular mechanisms of stress fiber formation between RGM1 epithelial cells, which were derived from rat gastric mucosa, and RGK1 cells, which were cancer-like mutants of RGM1. Our findings show that when PLP is used as a photosensitizer in PDT, it selectively induces necrosis in tumors with minimal impact on the surrounding normal tissues, as it is less likely to cause blood flow obstruction.

Indexed as

atomic force microscopy (AFM)autophagyphotodynamic therapy (PDT)porphylipoprotein (PLP)

Identifiers

PMID39683251

DOI10.3390/nano14231862

PMCPMC11643885

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.