Evidence map›Paper›PMID 39682812›Full record

ArticleFoods (Basel, Switzerland)2024

Screening of a Fraction with Higher Amyloid β Aggregation Inhibitory Activity from a Library Containing 210 Mushroom Extracts Using a Microliter-Scale High-Throughput Screening System with Quantum Dot Imaging.

Gegentuya Huanood, Mahadeva M M Swamy, Rina Sasaki, Keiya Shimamori, Masahiro Kuragano, Enkhmaa Enkhbat, Yoshiko Suga, Masaki Anetai, Kenji Monde, Kiyotaka Tokuraku

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gegentuya HuanoodGraduate School of Engineering, Muroran Institute of Technology, Muroran 050-8585, Japan.
Mahadeva M M SwamyFaculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Japan.
Rina SasakiGraduate School of Engineering, Muroran Institute of Technology, Muroran 050-8585, Japan.
Keiya ShimamoriGraduate School of Engineering, Muroran Institute of Technology, Muroran 050-8585, Japan.
Masahiro KuraganoGraduate School of Engineering, Muroran Institute of Technology, Muroran 050-8585, Japan.ORCID 0000-0002-4958-1286
Enkhmaa EnkhbatFaculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Japan.ORCID 0000-0002-2571-1154
Yoshiko SugaFaculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Japan.
Masaki AnetaiFaculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Japan.
Kenji MondeFaculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Japan.ORCID 0000-0002-1424-1054
Kiyotaka TokurakuGraduate School of Engineering, Muroran Institute of Technology, Muroran 050-8585, Japan.ORCID 0000-0002-7747-4808

Funding

Japan Science and Technology Agency JPMJPF2213JSPS KAKENHI JP24K08627JST SPRING JPMJSP2153
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a highly prevalent neurodegenerative disease hallmarked by amyloid plaques and neurofibrillary tangles. Amyloid plaques are formed by the amyloid β (Aβ) aggregation, so substances that inhibit this aggregation are useful for preventing and treating AD. Mushrooms are widely used medicinal fungi with high edible and nutritional value. Mushrooms have a variety of biologically active ingredients, and studies have shown that they have certain effects in anti-bacterial, anti-oxidation, anti-inflammatory, anti-tumor, and immune regulation. Previously, we developed a microliter-scale high-throughput screening (MSHTS) system using quantum dot (QD) nanoprobes to screen Aβ aggregation inhibitors. In this study, we appraised the Aβ aggregation inhibitory activity of 210 natural mushrooms from Hokkaido (Japan) and found 11 samples with high activity. We then selected

Indexed as

Alzheimer’s diseaseamyloid βinhibitormushroomnatural compoundsquantum dot nanoprobes

Identifiers

PMID39682812
PMCPMC11639962

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.