Capsaicin and Quercitrin Maintained Lipid Homeostasis of Hyperlipidemic Mice: Serum Metabolomics and Signaling Pathways.

Yanxia Wu, Weihua Liu, Rongrong Wang, Yunhe Lian, Xinying Cheng, Ruili Yang, Xianghong Wang, Si Mi

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yanxia WuCollege of Food Science and Technology, Hebei Agricultural University, No. 2596 Lekai South Street, Baoding 071000, China.

Weihua LiuCollege of Food Science and Technology, Hebei Agricultural University, No. 2596 Lekai South Street, Baoding 071000, China.

Rongrong WangCollege of Food Science and Technology, Hebei Agricultural University, No. 2596 Lekai South Street, Baoding 071000, China.

Yunhe LianChenguang Biotech Group Co., Ltd., Handan 057250, China.

Xinying ChengHebei Chenguang Testing Technical Services Co., Ltd., Handan 057250, China.

Ruili YangHebei Chenguang Testing Technical Services Co., Ltd., Handan 057250, China.

Xianghong WangCollege of Food Science and Technology, Hebei Agricultural University, No. 2596 Lekai South Street, Baoding 071000, China.

Si MiCollege of Food Science and Technology, Hebei Agricultural University, No. 2596 Lekai South Street, Baoding 071000, China.

Funding

National Natural Science Foundation of China 32202013Natural Science Foundation of Hebei Province of China C2022204222

6 · The paper itself

Abstract

Capsaicin and quercitrin have proved to be two major ingredients in fresh chili pepper. However, the effect of these two compounds on hyperlipidemia and the related molecular mechanisms were still unclear. This work was performed to examine the hypolipidemic capacity of capsaicin and quercitrin as well as the related signaling pathways. Hyperlipidemia was induced in mice by feeding them with a high-fat diet for 4 weeks. Both capsaicin and quercitrin were beneficial to inhibit a rise in fasting glucose, total cholesterol, total triglycerides, low-density lipoprotein cholesterol, and total bile acids and to lift the level of high-density lipoprotein cholesterol in the serum. The optimal lipid-lowering data were achieved in the capsaicin and quercitrin/3:1 group. Supplementation with capsaicin and quercitrin both singly and together in the feed caused a significant influence on the metabolite profiles of mouse serum. The signaling pathway for the hypolipidemic effect of capsaicin and quercitrin was related to the down-regulation of epidermal growth factor receptor (EGFR) but the up-regulation of phosphatidylin-ositol-3-kinase (PI3K), protein kinase Bb(Akt), farnesoid X receptor 1 (FXR1), and cholesterol 7α-hydroxylase (CYP7A1). This study confirmed the jointly hypolipidemic effect of capsaicin and quercitrin, which would benefit the valorization of chili pepper resources.

Indexed as

capsaicinhypolipidemic effectmetabolomicsquercitrinsignaling pathways

Identifiers

PMID39682799

DOI10.3390/foods13233727

PMCPMC11640311

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.