Evidence map›Paper›PMID 39682772›Full record

ArticleCells2024

Genome Instability and Senescence Are Markers of Cornelia de Lange Syndrome Cells.

Maddalena Di Nardo, Ian D Krantz, Antonio Musio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maddalena Di NardoInstitute for Biomedical Technologies, National Research Council, 56124 Pisa, Italy.ORCID 0000-0002-1481-2101
Ian D KrantzRoberts Individualized Medical Genetics Center, Division of Human Genetics, The Department of Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA.
Antonio MusioInstitute for Biomedical Technologies, National Research Council, 56124 Pisa, Italy.ORCID 0000-0001-7701-6543

Funding

Associazione Italiana per la Ricerca sul Cancro IG23284
6 · The paper itself

Abstract

Cornelia de Lange syndrome (CdLS) is a rare, dominantly inherited multisystem developmental disorder. Pathogenic variants in genes encoding the structural subunits and regulatory proteins of the cohesin complex (

Indexed as

Cell Cycle ProteinsCellular SenescenceChromosomal Proteins, Non-HistoneDe Lange SyndromeGenomic InstabilityBiomarkersCohesinsHistone DeacetylasesHumansOxidative StressRepressor ProteinsStructural Maintenance of Chromosome Protein 1BiomarkersCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsHDAC8 protein, humanHistone DeacetylasesNIPBL protein, humanRepressor ProteinsStructural Maintenance of Chromosome Protein 1cohesinCornelia de Lange syndromegenome instabilityHDAC8NIPBLoxidative stresssenescenceSMC1A

Identifiers

PMID39682772
PMCPMC11640591

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.