Deficiencies of Inducible Costimulator (ICOS) During Chronic Infection with

Rajesh Mani, Kanal E Balu, Yasuhiro Suzuki

Abstract read

In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Harnessing cellular immunity for next-generation vaccines against respiratory viruses: mechanisms, platforms, and optimization strategies.Frontiers in immunology · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rajesh ManiDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.

Kanal E BaluDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.

Yasuhiro SuzukiDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers · 2013 to 2026

$38.3M

Cooperation of CD8+ T cells and phagocytes to eliminate Toxoplasma cystsR01AI095032 · NIAID · UNIVERSITY OF KENTUCKY · PI SUZUKI, YASUHIRO · 2012 to 2023

$4.1M

National Institute of Allergy and Infectious Diseases R01AI095032NCI NIH HHS P30 CA177558NIAID NIH HHS R01 AI095032

6 · The paper itself

Abstract

We recently identified that the cerebral mRNA expression of inducible costimulator (ICOS) and its ligand, ICOSL, both significantly increase during the elimination of

Indexed as

CD28 AntigensCD8-Positive T-LymphocytesInducible T-Cell Co-Stimulator ProteinToxoplasmaToxoplasmosisAnimalsBrainChronic DiseaseCytotoxicity, ImmunologicFemaleMiceMice, Inbred C57BLMice, SCIDUp-RegulationCD28 AntigensIcos protein, mouseInducible T-Cell Co-Stimulator ProteinCD28CD8+ T cellcostimulatory moleculecytotoxic activityhost defenseICOSinfectionToxoplasma gondii

Identifiers

PMID39682747

DOI10.3390/cells13231998

PMCPMC11640114

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.