Evidence map›Paper›PMID 39682719›Full record

ArticleCells2024

CD38 Inhibitor 78c Attenuates Pro-Inflammatory Cytokine Expression and Osteoclastogenesis in Macrophages.

William Lory, Nityananda Chowdhury, Bridgette Wellslager, Subramanya Pandruvada, Yan Huang, Özlem Yilmaz, Hong Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Inhibition of CD38 by 78c Enhanced NADInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Inhibition of CD38 by 78c Enhanced NADInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

William LoryDepartment of Biomedical and Community Health Sciences, College of Dental Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Nityananda ChowdhuryDepartment of Biomedical and Community Health Sciences, College of Dental Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0002-8417-909X
Bridgette WellslagerDepartment of Biomedical and Community Health Sciences, College of Dental Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Subramanya PandruvadaDepartment of Biomedical and Community Health Sciences, College of Dental Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0001-9568-7666
Yan HuangDepartment of Endocrinology, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Özlem YilmazDepartment of Biomedical and Community Health Sciences, College of Dental Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0003-3487-7217
Hong YuDepartment of Biomedical and Community Health Sciences, College of Dental Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0002-0930-6810

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
CD38 signaling in aging-associated immune responses induced by oral pathogensR21DE033977 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Hong Yu · 2025 to 2026
$415k
Role of sphingosine-1-phosphate receptor 2 in osteoblastogenesis and bone regeneration in periodontitisR21DE030865 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YU, HONG · 2021 to 2022
$415k
Center for Healthy Aging, Medical University of South Carolina N/ANational Institute of Health R21DE030865, R21DE033977, and UL1 TR001450NCATS NIH HHS UL1 TR001450NIDCR NIH HHS R21 DE030865NIDCR NIH HHS R21 DE033977
6 · The paper itself

Abstract

CD38, a nicotinamide adenine dinucleotide (NAD

Indexed as

ADP-ribosyl Cyclase 1CytokinesMacrophagesOsteogenesisAggregatibacter actinomycetemcomitansAnimalsBone ResorptionMiceMice, Inbred C57BLNF-kappa BOsteoclastsPorphyromonas gingivalisRANK LigandADP-ribosyl Cyclase 1CytokinesNF-kappa BRANK Ligandbone lossCD38cytokineNAD+osteoclastpodosome

Identifiers

PMID39682719
PMCPMC11640151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.