ArticleDiagnostics (Basel, Switzerland)2024
The Impact of Microenvironment and Dysplasia Types on the Prognosis of Myelodysplastic Syndrome.
Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Ki-67 Expression in megakaryocytes: A new prognostic marker in Myelodysplastic Syndromes.Virchows Archiv : an international journal of pathology · 2026Article
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4 authors.
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Abstract
backgroundA detailed examination of bone marrow (BM) aspiration and biopsy can provide clues regarding the course of the disease as well as the diagnostic features of myelodysplastic syndrome (MDS).
methodsOur aim is to reveal the histomorphological features of MDS, investigate the impact of dysplasia types on prognosis, and highlight the importance of the microenvironment.
resultsIn 130 (93.5%) of 139 cases, Wright-Giemsa-stained BM aspiration slides were evaluated, and the dysplasia diversity was examined in detail. A regression analysis of dysplasia features significant for overall survival revealed that the presence of hyperlobulation in the megakaryocytic series (
conclusionsThe diversity of dysplasia in BM aspiration and biopsy does not predict MDS subtypes; however, certain cytomorphological dysplasia types can provide insights regarding survival. The microenvironment's impact on MDS pathogenesis is undeniable, with ALIP and MVD presence and frequency being significant factors. Thus, BM histomorphological examination, beyond its diagnostic role, also offers prognostic insights.
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