ArticleDiagnostics (Basel, Switzerland)2024
Non-Tuberculous Mycobacteria: Single Center Analyses of Risk Factors, Management and Mortality Outcomes of Adults with HIV.
Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Article
- Pulmonary Nontuberculous Mycobacterial Disease in a Tuberculosis-Endemic Setting: Two Cases Illustrating Diagnostic Pitfalls.Reports (MDPI) · 2026Article
- Article
- Mycobacterium kansasii in cancer patients: a 13-case series.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Observational
- Identification of a Novel Nucleic Acid Target for the Rapid and Specific Detection ofAvicenna journal of medical biotechnologyArticle
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Authors and funding
4 authors.
Funding
Abstract
BACKGROUND/
objectivesIn sub-Saharan Africa, there is paucity of data regarding non-tuberculous mycobacterial (NTM) infections, leading to underappreciation of disease burden. Consequently, fewer resources are allocated, leading to potential adverse outcomes. This study examines long-term mortality and risk factors of South African patients with positive NTM samples.
methodsWe conducted a retrospective analysis of clinical isolates of NTMs between 1 January 2010 and 30 June 2017. We retrieved and thoroughly reviewed the corresponding medical records of patients treated at Charlotte Maxeke Johannesburg Academic Hospital. Outcomes were compared between patients who underwent different therapy regimens, including macrolide-based regimens and 'watchful waiting'.
resultsA total of 123 patients were followed for a median of 1 year (interquartile range [IQR], 0.5-4.5). The median age was 39 years (IQR, 31-51) with male predominance, 58%. The common comorbid conditions were HIV (encountered in 78%) and previous TB (58%). Pulmonary disease due to
conclusionsAmong HIV patients, NTM-PD predominated, and not disseminated disease. MAC-PD was the most common infection. Low CD4 counts was a significant risk factor for early death, while sex, NTM species, macrolide therapy, and previous TB were not.
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