Evidence map›Paper›PMID 39682583›Full record

ReviewDiagnostics (Basel, Switzerland)2024

Diagnostic and Therapeutic Approaches to Jaw Osteoradionecrosis.

Yufan Wang, Heba Turkstani, Afrah Alfaifi, Sunday O Akintoye

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Evidence supporting endodontic therapy as a safe strategy in patients previously treated with head and neck radiotherapy: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  2. Review
  3. Review
  4. Post-COVID-19 Jaw Osteonecrosis: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026
    Review
  5. Radiographic classification of mandibular osteoradionecrosis: A blinded prospective multi-disciplinary interobserver diagnostic performance study.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2025
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yufan WangDepartment of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.
Heba TurkstaniDepartment of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0009-0000-7150-2073
Afrah AlfaifiDepartment of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sunday O AkintoyeDepartment of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-3090-1374

Funding

Biological Indicators of Racial Disparity in Ameloblastoma RecurrenceR01CA259307 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Sunday O Akintoye · 2022 to 2026
$1.8M
Novel therapeutic approaches to remediate radiotherapy-induced bone necrosisR56CA283140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI AKINTOYE, SUNDAY O · 2023 to 2023
$200k
National 1R56CA283140-01NCI NIH HHS R01 CA259307NCI NIH HHS R56 CA283140
6 · The paper itself

Abstract

Jaw osteoradionecrosis (ORN) is a major complication of head and neck cancer radiotherapy. Treatment complications account for most of the poor outcomes for head and neck cancers and the associated racial health disparities in cancer survivorship. The global incidence of jaw ORN is improving due to pre-radiotherapy patient preparations and improved head and neck cancer radiotherapy protocols. The diagnosis and management of jaw ORN are based on the patient's history and clinical presentation combined with radiological and histopathological tests. Evidence-based jaw ORN therapies focus on preventive, palliative, and surgical principles. However, new and innovative therapeutic approaches based on the cellular and molecular pathophysiological processes of jaw ORN and the jawbone's susceptibility to radiation bone damage are limited. The rationale for this narrative review is to highlight the current diagnostic approaches to jaw ORN and the pathophysiological basis for new therapeutic options for ORN.

Indexed as

diagnosisjawosteoradionecrosisradiationstem cellstherapy

Identifiers

PMID39682583
PMCPMC11640485

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.