Evidence map›Paper›PMID 39682560›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Could

Sergei E Titov, Evgeniya S Kozorezova, Sergei A Lukyanov, Sergei V Sergiyko, Pavel S Demenkov, Yulia A Veryaskina, Sergey L Vorobyev, Ilya V Sleptsov, Roman A Chernikov, Natalia I Timofeeva and 6 more

Abstract read
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In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sergei E TitovDepartment of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.ORCID 0000-0001-9401-5737
Evgeniya S KozorezovaNational Center of Clinical Morphological Diagnostics, Saint Petersburg 192283, Russia.ORCID 0000-0002-3659-7510
Sergei A LukyanovDepartment of General and Pediatric Surgery, South Ural State Medical University, Chelyabinsk 454092, Russia.ORCID 0000-0001-5559-9872
Sergei V SergiykoDepartment of General and Pediatric Surgery, South Ural State Medical University, Chelyabinsk 454092, Russia.
Pavel S DemenkovDepartment of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, Russia.ORCID 0000-0001-9433-8341
Yulia A VeryaskinaDepartment of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.ORCID 0000-0002-3799-9407
Sergey L VorobyevNational Center of Clinical Morphological Diagnostics, Saint Petersburg 192283, Russia.
Ilya V SleptsovDepartment of Endocrine Surgery, Saint Petersburg State University Hospital, Saint Petersburg 199034, Russia.
Roman A ChernikovDepartment of Endocrine Surgery, Saint Petersburg State University Hospital, Saint Petersburg 199034, Russia.ORCID 0000-0002-3001-664X
Natalia I TimofeevaDepartment of Endocrine Surgery, Saint Petersburg State University Hospital, Saint Petersburg 199034, Russia.ORCID 0000-0001-6594-8845
Svetlana V BarashkovaNational Center of Clinical Morphological Diagnostics, Saint Petersburg 192283, Russia.ORCID 0000-0002-5618-4510
Elena L LushnikovaDepartment of Molecular Pathology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk 630117, Russia.
Anna A UspenskayaDepartment of Endocrine Surgery, Saint Petersburg State University Hospital, Saint Petersburg 199034, Russia.ORCID 0000-0001-8430-6055
Anna V ZolotoukhoDepartment of Endocrine Surgery, Saint Petersburg State University Hospital, Saint Petersburg 199034, Russia.ORCID 0000-0003-1259-8188
Olga V RomanovaN.N. Blokhin National Medical Research Center of Oncology, Moscow 115478, Russia.
Igor F ZhimulevDepartment of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.

Funding

Russian Science Foundation 20-14-00074-P
6 · The paper itself

Abstract

BACKGROUND/

objectivesA modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searching for the preoperative molecular genetic markers of high-grade papillary thyroid carcinoma (PTC HG), primarily because of a recent WHO reclassification and singling out of a separate entity: high-grade follicular cell-derived nonanaplastic thyroid carcinoma. Therefore, this work was aimed at identifying PTC HG-specific microRNAs and mRNAs that reliably distinguish them from differentiated papillary thyroid carcinoma in preoperative cytology specimens (fine-needle aspiration biopsies).

methodsA molecular genetic profile (expression levels of 14 genes and eight microRNAs) was studied in 110 cytology specimens from patients with PTC: 13 PTCs HG and 97 PTCs without features of HG.

resultsOf the examined eight microRNAs and 14 genes, significant differences in the expression levels between the PTC and PTC HG groups were revealed for genes

conclusionsEarly preoperative diagnosis of PTC HG in patients with early stages of this cancer type will allow clinicians to modify a treatment strategy toward a larger surgery volume and lymph node dissection and may provide indications for subsequent radioactive iodine therapy.

Indexed as

high-grade carcinomamolecular markerpapillary thyroid carcinomapreoperative diagnosisSLC26A7

Identifiers

PMID39682560
PMCPMC11640196

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.