Evidence map›Paper›PMID 39682372›Full record

ArticleAnimals : an open access journal from MDPI2024

A Pilot Study to Assess the Safety and Efficacy of Umbilical Cord Blood-Derived Mesenchymal Stromal Cells for the Treatment of Synovitis in Horses.

Kathryn Seabaugh, Sangeeta Rao, Judith B Koenig, Lynn Pezzanite, Steven Dow, Thomas G Koch, Keith A Russell, Sahar Mehrpouyan, A Hamed Alizadeh, Laurie R Goodrich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kathryn SeabaughOrthopaedic Research Center, Translational Medicine Institute, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-3088-8827
Sangeeta RaoDepartment of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-9234-0082
Judith B KoenigDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G2W1, Canada.ORCID 0000-0003-4872-9231
Lynn PezzaniteOrthopaedic Research Center, Translational Medicine Institute, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0003-4990-5006
Steven DowOrthopaedic Research Center, Translational Medicine Institute, Colorado State University, Fort Collins, CO 80523, USA.
Thomas G KocheQcell Inc., University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada.
Keith A RusselleQcell Inc., University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada.
Sahar MehrpouyaneQcell Inc., University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada.
A Hamed AlizadeheQcell Inc., University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada.
Laurie R GoodrichOrthopaedic Research Center, Translational Medicine Institute, Colorado State University, Fort Collins, CO 80523, USA.

Funding

eQcell, Inc na
6 · The paper itself

Abstract

Synovitis is present before and during osteoarthritis in horses and can result in performance-limiting lameness. Twenty-four horses with lameness localized to the metacarpo-/metatarsophalangeal joint or a single joint of the carpus were enrolled in this study. We evaluated the response of intra-articular injection with 10 million activated (aMSC) or non-activated (naMSC) allogeneic equine umbilical cord blood-derived mesenchymal stromal cells (MSCs). Subjective and objective lameness was assessed on Days 0, 1, 21, and 42. The treatment injection was randomly assigned and performed following the baseline assessment on Day 0. naMSC-treated horses had straight-line lameness scores that were significantly lower on Day 21 (1.0 ± 1.15) and Day 42 (1.13 ± 1.00) than on Day 0 (

Indexed as

equine lamenessequine umbilical cord blood-derived mesenchymal stromal cellssynovitis

Identifiers

PMID39682372
PMCPMC11640105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.