Evidence map›Paper›PMID 39682281›Full record

ReviewCancers2024

Sirtuins as Key Regulators in Pancreatic Cancer: Insights into Signaling Mechanisms and Therapeutic Implications.

Surbhi Chouhan, Anil Kumar, Naoshad Muhammad, Darksha Usmani, Tabish H Khan

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. SIRT1: Protean roles at the nexus of health, disease, and therapeutics.Journal of cell communication and signaling · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. A Novel MICB-Targeting CAR-NK Cells for the Treatment of Pancreatic Cancer.International journal of molecular sciences · 2026
    Article
  13. Article
  14. Review
  15. Article
  16. CouldBiomedicines · 2025
    Article
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Surbhi ChouhanLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX 75235, USA.ORCID 0000-0001-6055-525X
Anil KumarDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.ORCID 0000-0003-2287-5388
Naoshad MuhammadDepartment of Radiation Oncology, School of Medicine, Washington University, St. Louis, MO 63130, USA.
Darksha UsmaniDepartment of Ophthalmology, Washington University School of Medicine, St. Louis, MO 63130, USA.
Tabish H KhanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63130, USA.ORCID 0000-0002-0143-7496

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most lethal cancers, marked by rapid progression, pronounced chemoresistance, and a complex network of genetic and epigenetic dysregulation. Within this challenging context, sirtuins, NAD

Indexed as

cancer signaling pathwaysdeacetylasepancreatic cancerpancreatic ductal adenocarcinoma (PDAC)SIRTsirtuinstherapeutic interventions

Identifiers

PMID39682281
PMCPMC11640239

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.