Evidence map›Paper›PMID 39682198›Full record

ArticleCancers2024

Effect of Distress, Anxiety, and Depressive Symptoms on SARS-CoV-2 mRNA BNT162b2 Vaccine Efficacy in Cancer Patients.

Gabriella Rondanina, Tania Buttiron Webber, Oriana D'Ecclesiis, Marco Musso, Irene Maria Briata, Nicoletta Provinciali, Monica Boitano, Matteo Clavarezza, Mauro D'Amico, Carlotta Defferrari and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Gabriella RondaninaOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.
Tania Buttiron WebberOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.ORCID 0000-0002-3605-2828
Oriana D'EcclesiisEuropean Institute of Oncology IRCCS, 20141 Milan, Italy.
Marco MussoIST Nord-Centro Risorse Biologiche, Policlinico San Martino, 16132 Genoa, Italy.ORCID 0000-0001-6571-7609
Irene Maria BriataOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.ORCID 0000-0003-0767-0026
Nicoletta ProvincialiOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.ORCID 0000-0002-7803-3852
Monica BoitanoOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.
Matteo ClavarezzaOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.
Mauro D'AmicoOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.ORCID 0000-0001-5821-3410
Carlotta DefferrariOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.
Alberto GozzaOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.
Leonello InnocentiOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.
Alessio CarboneOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.ORCID 0009-0008-9907-3299
Martino OlivaOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.ORCID 0009-0004-5913-9258
Emanuela MarcenaroDepartment of Experimental Medicine (DIMES), University of Genoa, 16126 Genova, Italy.ORCID 0000-0003-4103-7566
Francesca FilauroOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.
Sara GandiniEuropean Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-1348-4548
Andrea DeCensiOncology Department, E.O. Ospedali Galliera, 16128 Genoa, Italy.ORCID 0000-0003-2635-4491

Funding

This study is supported by E.O. Ospedali Galliera, Genoa, Italy, Associazione WeCare and Lions Club Genoa Sant'Agata, Italy. The European Institute of Oncology, Milan, Italy is partially sup-ported by the Italian Ministry of Health with Ricerca Corrente a No 101046016
6 · The paper itself

Abstract

BACKGROUND/

objectivesOur previous study of 291 cancer patients, we showed that 20% did not respond to two doses of COVID-19 vaccine administered six weeks apart.

methodsHere, we investigated if psychological factors (distress, anxiety, and depressive symptoms) affected antibody response and markers of vaccine activation (D-dimer) after 6 months from initial vaccination.

resultsOverall, 31 subjects (14.2%) had no antibody response at 6 months. Our analysis revealed significant predictors of vaccine failure, including the stage of metastatic disease and high-stress levels (OR = 2.46, 95% CI, 1.05-5.77,

conclusionsThese findings underscore a critical association between elevated psychological distress and reduced immune responses to the COVID-19 vaccine, emphasizing the urgent need for targeted psychological and behavioral support within this vulnerable population.

Indexed as

anxiety disordersCOVID-19 vaccinesC reactive proteinD dimerdepressive disorderimmunogenicityneoplasmspsychological distressvaccine

Identifiers

PMID39682198
PMCPMC11640422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.