Evidence map›Paper›PMID 39682144›Full record

ArticleCancers2024

Exploring Genomic Biomarkers for Pembrolizumab Response: A Real-World Approach and Patient Similarity Network Analysis Reveal DNA Response and Repair Gene Mutations as a Signature.

Marco Filetti, Mario Occhipinti, Alessio Cirillo, Fabio Scirocchi, Alessio Ugolini, Raffaele Giusti, Pasquale Lombardi, Gennaro Daniele, Andrea Botticelli, Giuseppe Lo Russo and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marco FilettiPhase 1 Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy.
Mario OcchipintiDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Alessio CirilloDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-0449-9569
Fabio ScirocchiDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-6408-2055
Alessio UgoliniDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-5970-9693
Raffaele GiustiDepartment of Medical Oncology, St. Andrea Hospital, 00189 Rome, Italy.ORCID 0000-0003-4592-8868
Pasquale LombardiPhase 1 Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy.ORCID 0000-0001-6262-2161
Gennaro DanielePhase 1 Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy.ORCID 0000-0001-5360-1895
Andrea BotticelliDepartment of Radiology, Oncological and Anatomo-Pathological Science, Sapienza University of Rome, 00161 Rome, Italy.
Giuseppe Lo RussoThoracic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
Filippo De BraudOncology and Hemato-Oncology Department, University of Milan, 20133 Milan, Italy.
Paolo MarchettiIstituto Dermopatico dell'Immacolata IDI-IRCCS, 00167 Rome, Italy.ORCID 0000-0002-9064-8761
Marianna NutiDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-1809-1003
Elisabetta FerrettiDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-7265-6429
Lorenzo FarinaDepartment of Computer, Control, and Management Engineering, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-8314-6029
Aurelia RughettiDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-1863-8251
Manuela PettiDepartment of Computer, Control, and Management Engineering, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-0149-161X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA damage response and repairimmunotherapynetwork analysisnever-smokernon-small cell lung cancer

Identifiers

PMID39682144
PMCPMC11639826

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.