Evidence map›Paper›PMID 39682110›Full record

ArticleCancers2024

Comparing Outcomes of Open and Robot-Assisted Inguinal Lymphadenectomy for the Treatment of cN2 Squamous Cell Carcinoma of the Penis: A Retrospective Single-Center Analysis.

Aldo Brassetti, Rigoberto Pallares-Mendez, Alfredo M Bove, Leonardo Misuraca, Umberto Anceschi, Gabriele Tuderti, Riccardo Mastroianni, Leslie C Licari, Eugenio Bologna, Silvia Cartolano and 6 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Aldo BrassettiDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.ORCID 0000-0001-9643-8979
Rigoberto Pallares-MendezDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.ORCID 0000-0001-6112-1672
Alfredo M BoveDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.ORCID 0000-0002-5139-9993
Leonardo MisuracaDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.
Umberto AnceschiDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.
Gabriele TudertiDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.
Riccardo MastroianniDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.ORCID 0000-0003-3708-2209
Leslie C LicariDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.ORCID 0000-0002-3274-1247
Eugenio BolognaDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.ORCID 0000-0002-1140-0590
Silvia CartolanoDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.
Simone D'AnnunzioDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.
Mariaconsiglia FerrieroDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.
Rocco S FlammiaDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.
Flavia ProiettiDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.ORCID 0000-0002-6478-8584
Costantino LeonardoDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.
Giuseppe SimoneDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 43, 00143 Rome, Italy.ORCID 0000-0002-4868-9025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInguinal lymph node (LN) dissection (iLND) is mandatory in cN2 penile squamous cell carcinoma (PSCC). Open iLND (OIL) is often omitted due to the high rate of complications. A minimally invasive approach may reduce morbidity; however, evidence supporting its role to treat bulky nodes is limited. This study aimed to present the outcomes of the largest European single-center series of robot-assisted iLND (RAIL) for the treatment of cN2 PSCC and to compare the surgical and survival outcomes of this approach with the standard of care.

methodsA retrospective analysis was conducted on men with cT1-4N2M0 PSCC undergone either OIL or RAIL at our institution from January 2014 onwards. Baseline demographics, perioperative data, and oncologic outcomes were analyzed.

resultsOverall, 47 patients were included; 38 (81%) underwent OIL. Median age was 59 years, with 23 men (48%) presenting with a ≥4 Charlson comorbidity index. Operation time was significantly longer in the robotic cohort (212 min vs. 145 min;

conclusionsRAIL demonstrated comparable perioperative and oncologic outcomes to OIL for cN2 PSCC, with the benefit of reduced estimated blood loss. RAIL is a feasible option for cases where a minimally invasive approach is preferred, offering comparable perioperative safety and oncological outcomes.

Indexed as

lymph node excisionpenile cancerpenile neoplasmsrobot-assisted inguinal lymphadenectomyrobotic surgical procedures

Identifiers

PMID39682110
PMCPMC11640663

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.