Evidence map›Paper›PMID 39682096›Full record

ReviewCancers2024

The Synergy of Thermal and Non-Thermal Effects in Hyperthermic Oncology.

Carrie Anne Minnaar, Gyula Peter Szigeti, Andras Szasz

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carrie Anne MinnaarDepartment of Radiation Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa.ORCID 0000-0003-3692-7134
Gyula Peter SzigetiJohn von Neumann Faculty of Informatics, Óbuda University, 1034 Budapest, Hungary.ORCID 0000-0003-0411-9992
Andras SzaszDepartment of Biotechnics, Hungarian University of Agriculture and Life Sciences, 2100 Gödöllő, Hungary.ORCID 0000-0002-4939-1183

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundModulated electro-hyperthermia (mEHT) is unique due to its combination of thermal and non-thermal effects.

methodThis report summarizes the literature on the effects of mEHT observed in vitro and in vivo.

resultsThe thermal and electrical heterogeneity of tissues allows the radiofrequency signal to selectively target malignant tissue. The applied modulation appears to activate various apoptotic pathways, predominantly leading to immunogenic cell death (ICD). ICD promotes the release of damage-associated molecular patterns, potentially producing tumour-specific antigen-presenting cells. This abscopal-type effect may target distant metastases while treating the primary tumour locally. This immune memory effect is like vaccination mechanisms.

conclusionsThe application of mEHT has the potential to expand from local to systemic disease, enabling the simultaneous treatment of micro- and macro-metastases.

Indexed as

abscopal effectcancer vaccinationcellular selectiondamage-associated molecular pattern (DAMP)heterogenic heatingimmunogenic cell death (ICD)non-thermal actionsthermal processes

Identifiers

PMID39682096
PMCPMC11639953

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.