Evidence map›Paper›PMID 39682083›Full record

ArticleCancers2024

Upfront Surgery vs. Endoscopic Stenting Bridge to Minimally Invasive Surgery for Treatment of Obstructive Left Colon Cancer: Analysis of Surgical and Oncological Outcomes.

Mauro Marzano, Paolo Prosperi, Gian Luca Grazi, Fabio Cianchi, Luca Talamucci, Damiano Bisogni, Lapo Bencini, Manuela Mastronardi, Tommaso Guagni, Agostino Falcone and 3 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mauro MarzanoEmergency Surgery Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.ORCID 0000-0003-4816-6504
Paolo ProsperiEmergency Surgery Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.
Gian Luca GraziHepatobiliary Pancreatic Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.ORCID 0000-0002-3279-0313
Fabio CianchiDigestive System Surgery Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.ORCID 0000-0002-6936-8693
Luca TalamucciAdvanced Interventional Endoscopy Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.
Damiano BisogniAdvanced Interventional Endoscopy Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.
Lapo BenciniGeneral Surgery Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.
Manuela MastronardiDepartment of Medicine, Surgery and Health Sciences, General Surgery Unit, University Hospital of Trieste, Strada di Fiume 447, 34149 Trieste, Italy.ORCID 0000-0003-3525-3692
Tommaso GuagniEmergency Surgery Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.ORCID 0000-0003-2038-5748
Agostino FalconeEmergency Surgery Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.ORCID 0009-0009-4885-7728
Jacopo MartellucciEmergency Surgery Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.ORCID 0000-0002-7437-9098
Carlo BergaminiEmergency Surgery Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.
Alessio GiordanoEmergency Surgery Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.ORCID 0000-0002-9505-791X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft colon cancer obstruction treatment is a debated topic in the literature. Stent placement is effective as a bridge-to-surgery strategy, but there are some concerns about the oncological safety for the reported higher risk of local and peritoneal recurrence. This study aims to compare the surgical and oncological outcomes of patients treated with stent followed by elective surgery with those treated with primary resection.

methodsThis is a retrospective observational study. We included patients of both sexes, ≥18 years old, with a histological diagnosis of intestinal adenocarcinoma, and admitted to our hospital for left colon cancer obstruction demonstrated by CT scan without metastasis or perforation. They were treated through primary resection (PR) or stent placement followed by elective surgery (SR). The two groups were compared for general characteristics, surgical outcomes, and oncological outcomes (metastasis and local recurrence) at 30 days, 90 days, 1 year, and 3 years. Post-operative quality of life (QoL) was also investigated.

resultsThe SR group showed a shorter hospital stay, a lower post-operative mortality, a lower stoma rate at 1 year, and a higher number of minimally invasive procedures. Oncological outcomes were not different compared to the PR group. The SR group demonstrated better QoL in two out of six items on the EQ-5D-5L test.

conclusionsStent placement as a bridge-to-surgery strategy is feasible and provides better surgical outcomes in terms of post-operative complications, surgical approach, stoma rate, and QoL. Oncological outcomes were not reported differently, but further studies should be conducted to better evaluate this aspect.

Indexed as

colorectal cancerendoscopic stentingintestinal obstructionleft colon cancerminimally invasive surgery

Identifiers

PMID39682083
PMCPMC11640554

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.