Evidence map›Paper›PMID 39681926›Full record

ReviewBMC global and public health2024

Nutritionally acquired immunodeficiency must be addressed with the same urgency as HIV to end tuberculosis.

Madolyn R Dauphinais, Kobto G Koura, Prakash Babu Narasimhan, Saurabh Mehta, Julia L Finkelstein, Scott K Heysell, Pranay Sinha

Abstract readReview
In one paragraph

Review in BMC global and public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Energy dense nutritional supplements improve weight gain among malnourished adults with drug-sensitive pulmonary tuberculosis: An open-label randomized controlled trial in Faridabad, India.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
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  20. Clearing the air: microcosting the carbon impact of drug-susceptible pulmonary TB treatment.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Madolyn R DauphinaisBoston Medical Center, 801 Massachusetts Ave, Crosstown Center, Suite 2021A, Boston, MA, 02118, USA.
Kobto G KouraInternational Union Against Tuberculosis and Lung Disease, Paris, France.
Prakash Babu NarasimhanDepartment of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Saurabh MehtaCenter for Precision Nutrition and Health, Cornell University, Ithaca, NY, USA.
Julia L FinkelsteinCenter for Precision Nutrition and Health, Cornell University, Ithaca, NY, USA.
Scott K HeysellDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA.
Pranay SinhaBoston Medical Center, 801 Massachusetts Ave, Crosstown Center, Suite 2021A, Boston, MA, 02118, USA. psinha@bu.edu.

Funding

Urine Colorimetry for Tuberculosis Pharmacokinetics Evaluation in Children and AdultsR01AI137080 · NIAID · UNIVERSITY OF VIRGINIA · PI Scott K Heysell, Leonid Kagan · 2018 to 2026
$6.3M
Developing research leaders at the intersection of malnutrition and tuberculosis in TanzaniaD43TW012247 · FIC · UNIVERSITY OF VIRGINIA · PI Scott K Heysell, STELLAH GEORGE MPAGAMA · 2022 to 2026
$1.4M
Nutritional Interventions to End Tuberculosis among Persons with HIV (NUTRIENT)K01AI167733 · NIAID · BOSTON MEDICAL CENTER · PI Pranay Sinha · 2023 to 2026
$512k
CRDF Global DAA3-19-65673-1FIC NIH HHS D43 TW012247NIAID NIH HHS K01 AI167733NIAID NIH HHS R01 AI137080Warren Alpert Foundation 6005415
6 · The paper itself

Abstract

Tuberculosis (TB) is the leading infectious killer worldwide, with 10.6 million cases and 1.6 million deaths in 2021 alone. One in 5 incident TB cases were attributable to malnutrition, more than double the fraction attributed to HIV. Like HIV, malnutrition is a cause of secondary immunodeficiency and has even been dubbed nutritionally acquired immunodeficiency syndrome (N-AIDS). However, malnutrition remains the neglected cousin of HIV in global TB elimination efforts. Malnutrition increases the risk for TB progression, increases disease severity, and worsens TB treatment outcomes. Thus, it is both a TB determinant and comorbidity. In this perspective, we discuss decades of data to make the case that N-AIDS, just like HIV/AIDS, also deserves special consideration in the TB elimination discourse. Fortunately, malnutrition is a modifiable risk factor and there is now empirical evidence that addressing nutrition can help us curb the TB pandemic. Recognizing malnutrition as a key determinant and comorbidity is key to detecting and treating the missing millions while also preventing additional millions from suffering TB disease.

Indexed as

HIVMalnutritionTuberculosis

Identifiers

PMID39681926
PMCPMC11622872

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.