ArticleJournal of cosmetic dermatology2025
Preparation and Characterization of Injectable Augmentation Gels Containing Polycaprolactone and Hyaluronic Acid.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Regenerative Functional Microspheres for Aesthetic Medicine: Mechanism, Materials, Fabrication, and Clinical Applications.Advanced healthcare materials · 2026Review
- Sahara Desert sand "Chitligsan": characterisation and assessment of antibacterial activity and cytotoxicity.RSC advances · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundInjectable augmentation gels are widely used in the treatment of soft tissue. The composition of these gels has to be continuously improved due to the limitations of the currently available formulations.
aimsThis study focuses on the development of an innovative injectable gel designed to address current trends and specific needs within the field.
methodsThe current study utilized a safer hyaluronic acid (HA) gel carrier, created with a less toxic cross-linker, in combination with polycaprolactone (PCL) microspheres at various concentrations. PCL microspheres were prepared using an emulsification-solvent evaporation technique. Six different gel formulations were developed using PCL microspheres and biphasic HA gel structures.
resultsThe produced microspheres had non-agglomerated, smooth surfaces with an average particle size of approximately 45 ± 0.14 μm. The rheological results of the PCL-HA6 such as storage modulus (G', Pa), loss modulus (G", Pa), complex viscosity (η*), and phase angle (°) at 1 Hz frequency were measured as 553.97 ± 32.48, 368.4 ± 12.24, 105.9 ± 5.27, and 33.65 ± 0.92, respectively, and the injection force was measured as 9.64 ± 1.46. In vitro tests revealed that the PCL-HA6 group showed the highest cell viability compared to the other groups and provided a relative increase in collagen production over time, as demonstrated by the relevant gene expression.
conclusionsThe developed PCL/HA gel exhibited biocompatibility and non-toxicity, making it a safe option for soft tissue augmentation. It demonstrated potential for medical applications and exhibited favorable rheological characteristics and injectability.
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Registered trials
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