Evidence map›Paper›PMID 39681797›Full record

ArticleArchives of virology2024

Detection of a novel hepacivirus in wild cavies (Cavia aperea aperea).

Gabriela Espíndola Birlem, Alexandre Sita, Juliana Schons Gularte, Deivid de Souza da Silva, Meriane Demoliner, Paula Rodrigues de Almeida, Juliane Deise Fleck, Fernando Rosado Spilki, Severino Silvano Dos Santos Higino, Sergio Santos de Azevedo and 1 more

Abstract read
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In one paragraph

Article in Archives of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gabriela Espíndola BirlemLaboratório de Microbiologia Molecular, Universidade Feevale, Novo Hamburgo, RS, Brazil.
Alexandre SitaLaboratório de Microbiologia Molecular, Universidade Feevale, Novo Hamburgo, RS, Brazil.
Juliana Schons GularteLaboratório de Microbiologia Molecular, Universidade Feevale, Novo Hamburgo, RS, Brazil.
Deivid de Souza da SilvaLaboratório de Microbiologia Molecular, Universidade Feevale, Novo Hamburgo, RS, Brazil.
Meriane DemolinerLaboratório de Microbiologia Molecular, Universidade Feevale, Novo Hamburgo, RS, Brazil.
Paula Rodrigues de AlmeidaLaboratório de Microbiologia Molecular, Universidade Feevale, Novo Hamburgo, RS, Brazil.
Juliane Deise FleckLaboratório de Microbiologia Molecular, Universidade Feevale, Novo Hamburgo, RS, Brazil.
Fernando Rosado SpilkiLaboratório de Microbiologia Molecular, Universidade Feevale, Novo Hamburgo, RS, Brazil.
Severino Silvano Dos Santos HiginoUnidade Acadêmica de Medicina Veterinária, Universidade Federal de Campina Grande (UFCG), Patos, PB, Brazil.
Sergio Santos de AzevedoUnidade Acadêmica de Medicina Veterinária, Universidade Federal de Campina Grande (UFCG), Patos, PB, Brazil.
Matheus Nunes WeberLaboratório de Imunologia e Biologia Molecular, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. matheus.weber@ufrgs.br.ORCID http://orcid.org/0000-0001-8282-6778

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 405786/2022-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 23/2551-0000143-8Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 23/2551-0002221-4
6 · The paper itself

Abstract

Hepacivirus is a genus of RNA viruses within the family Flaviviridae of which hepatitis C virus (HCV) is the prototype. Several hepaciviruses have been identified in mammals, including rodents of multiple families. Each rodent hepacivirus described so far has been found only in members of a single rodent species. Here, we report the discovery and characterization of a putative new genotype of an unclassified rodent hepacivirus in a wild cavy (Cavia aperea aperea) that was reported previously in Proechimys semispinosus. This virus was detected in one out of 14 (7.14%) wild cavy sera tested by RT-PCR. The complete genome sequence was obtained by high-throughput sequencing using an Illumina MiSeq platform. This is the first report of a hepacivirus in a member of the family Caviidae. Our findings show that members of different rodent species and even families can be infected by hepaciviruses of the same species. The identification and characterization of novel hepaciviruses might lead to the discovery of reservoirs of viruses that are genetically related to human pathogens, and this can help to elucidate the evolutionary origins of HCV and other hepaciviruses.

Indexed as

Genome, ViralHepacivirusHepatitis CPhylogenyAnimalsAnimals, WildGenotypeHigh-Throughput Nucleotide SequencingRNA, ViralRNA, Viral

Identifiers

PMID39681797

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.