Evidence map›Paper›PMID 39681780›Full record

Trial reportInternational journal of behavioral medicine2026

Tai Chi and Wellness Interventions for Veterans with Gulf War Illness: A Randomized Controlled Feasibility Trial.

Barbara L Niles, Anica Pless Kaiser, Thomas Crow, Maria McQuade, Craig Polizzi, Carole Palumbo, Maxine Krengel, Kimberly Sullivan, Chenchen Wang, DeAnna L Mori

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in International journal of behavioral medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Barbara L NilesNational Center for PTSD, VA Boston Healthcare System and Boston University Chobanian & Avedisian School of Medicine, 150 South Huntington Avenue (Office 12B-53C), Boston, MA, 02130, USA. Barbara.Niles@va.gov.ORCID http://orcid.org/0000-0002-2342-9737
Anica Pless KaiserNational Center for PTSD, VA Boston Healthcare System and Boston University Chobanian & Avedisian School of Medicine, 150 South Huntington Avenue (Office 12B-53C), Boston, MA, 02130, USA.ORCID http://orcid.org/0000-0002-4803-0191
Thomas CrowNational Center for PTSD, VA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6227-2069
Maria McQuadeNational Center for PTSD, VA Boston Healthcare System, Boston, MA, USA.
Craig PolizziNational Center for PTSD, VA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9270-6868
Carole PalumboVA Boston Healthcare System, Boston University, Chobanian & Avedisian School of Medicine, Boston University School of Public Health, Boston, MA, USA.
Maxine KrengelVA Boston Healthcare System and Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Kimberly SullivanBoston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7940-6123
Chenchen WangTuft Medicine and Tufts Medical Center, Boston, MA, USA.
DeAnna L MoriVA Boston Healthcare System and Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8156-7364

Funding

Tai Chi Mind-body Exercise for the Treatment of Post-traumatic Stress DisorderR01AT006367 · NCCIH · TUFTS MEDICAL CENTER · PI WANG, CHENCHEN · 2011 to 2014
$2.9M
Tai Chi for Knee OsteoarthritisR01AT005521 · NCCIH · TUFTS MEDICAL CENTER · PI WANG, CHENCHEN · 2010 to 2013
$2.4M
Mentoring and Research in Patient-Oriented Integrative MedicineK24AT007323 · NCCIH · TUFTS MEDICAL CENTER · PI WANG, CHENCHEN · 2014 to 2023
$1.8M
CSRD VA I01 CX001422NCCIH NIH HHS K24 AT007323NCCIH NIH HHS K24AT007323NCCIH NIH HHS R01 AT005521NCCIH NIH HHS R01AT005521NCCIH NIH HHS R01 AT006367NCCIH NIH HHS R01AT006367U.S. Department of Veterans Affairs SPLD-004-15S
6 · The paper itself

Abstract

backgroundGulf War Illness (GWI) is a chronic multi-symptom illness that affects up to one-third of the 700,000 American military personnel deployed to the Persian Gulf region in 1990 and 1991. We conducted a randomized controlled trial to examine feasibility and the relative efficacy of two 12-week in-person group treatments (Tai Chi and Wellness) to address GWI symptoms of chronic pain, fatigue, and changes in mood and cognitive functioning.

methodMale and female veterans were randomly assigned to Tai Chi (n = 27) or Wellness (n = 26) group interventions and assessed at four time points: baseline, post-treatment, 3-, and 9-month follow-up. Multilevel models with a treatment-by-time interaction term were utilized to evaluate treatment effects and changes in GWI-related outcomes over time.

resultsSatisfaction was high, there were no adverse events, and over half the participants attended 75% or more sessions with no significant differences between groups. For pain interference, analyses revealed a significant quadratic effect of time with no differences between treatment groups. For general fatigue and a cognitive test of trail making, no significant effects were detected. For depressed mood, linear and quadratic time effects and the group x linear time interaction were significant indicating greater reductions for Tai Chi participants. For a verbal learning test, linear and quadratic time and the group x quadratic time interaction significantly predicted total recall with Tai Chi participants demonstrating more rapid initial improvements.

conclusionFindings indicate that both Tai Chi and Wellness are feasible and acceptable. Both interventions may have a salutary impact on pain interference, depression, and verbal learning with some advantages for Tai Chi.

Indexed as

Persian Gulf SyndromeTai JiVeteransAdultAffectChronic PainCognitionFatigueFeasibility StudiesFemaleHumansMaleMiddle AgedPatient SatisfactionTreatment OutcomeComplementaryGulf War IllnessIntegrativeTai ChiVeteranWellness

Identifiers

PMID39681780
PMCPMC12167744

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.