ArticleClinical rheumatology2025
Correlation of systemic immune inflammation and serum uric acid with gout: based on NHANES.
Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Systemic Immune-Inflammation Index is associated with flare-related and intercritical inflammatory activity in gout: a longitudinal real-world repeated-measures study.Rheumatology international · 2026Article
- Machine learning based on systemic inflammation response index and risk of cardiovascular disease in gout: a retrospective study and clinical validation.Clinical rheumatology · 2026Article
- Association between autoimmune thyroiditis and rheumatoid arthritis: a cross-sectional risk stratification study.Frontiers in endocrinology · 2026Article
- Evaluation of the role of inflammation in fibromyalgia through haematological indices: A retrospective study.The Indian journal of medical research · 2025Article
- Correlation of systemic immune inflammation and serum uric acid with gout: based on NHANES.Clinical rheumatology · 2025Article
- Exploring Immunological Determinants and Constructing a Predictive Model for for Diagnosis of Gout: Insights Into Immune Biomarkers.Journal of inflammation research · 2025Article
- Advancing Gouty Arthritis Research: The Clinical Value of Complete Blood Cell Count Ratios and Immune-Inflammatory Interactions.Journal of inflammation research · 2025Review
- Association between advanced lung cancer inflammation index and acute gouty arthritis in Dalian, China: a cross-sectional study.Frontiers in nutrition · 2025Article
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2 authors.
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Abstract
objectivesThis study aimed to explore the relationship of systemic immune inflammation index (SII) and uric acid with gout using NHANES 2017-2018 data.
methodData were collected from the 2017-2018 circle of the NHANES database. SII was calculated based on the counts of lymphocytes (LC), neutrophils (NC), and platelets (PC). Data on gout patients were collected from questionnaires. Logistic regression analysis and subgroup analysis were used to explore the relationship between SII and gout.
resultsA total of 4517 participants were included in the study, with 273 individuals in the gout group and 4244 in the non-gout group. Logistic regression analysis showed that SII and serum uric acid were higher in the gout group than those in the non-gout group. SII ≥ 511.8 and uric acid ≥ 7.0 mg/dL may be positively associated with gout. Further subgroup analysis revealed that the level of SII was positively associated with gout in the female group and the group with eGFR of 60-89.9 mL/min/1.73 m
conclusionsThere are positive correlations of SII and serum uric acid with gout. Our study suggests that SII could be a novel, valuable, and feasible inflammatory marker for gout. Key Points • Gout is a joint disease associated with hyperuricemia. The mechanism of the disease involves multiple complex factors, including metabolic disorders and inflammation. • Systemic immune inflammation index (Sll), as an evaluation index of systemic inflammatory responses, can reflect the body's inflammatory changes when the immune system is continuously activated with chronic inflammation of joints and other tissues. • We used the NHANES database to explore the relationship of SII and uric acid with gout, providing a basis for the diagnosis of gout and prognostic assessment of gout patients.
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