ArticlePediatric cardiology2025
Expression Profile of TGFB1 Gene in Pediatric Patients with Isolated Bicuspid Aortic Valve.
Article in Pediatric cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Genetic analysis of TGFBI variants in the Taiwanese population: from granular corneal dystrophy type 1 to a broader phenotypic spectrum.American journal of translational research · 2026Article
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5 authors.
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Abstract
Studies on the genetic basis of bicuspid aortic valve (BAV), characterized by a configuration of the aortic valve with two leaflets instead of three, are insufficient. This study aimed to elucidate the possible relationship between BAV and TGF-β1 gene expression levels. Forty-eight pediatric patients diagnosed with isolated BAV and 50 healthy children with innocent heart murmurs were included in the study. A comprehensive transthoracic echocardiographic examination was performed using the Vivid S5 Pro Ultrasound for all children. TGF-β1 gene expression levels were detected by RT-PCR method. The mean age of the patients was 8.54 ± 5.3 years, and the mean age of the children in the control group was 7.07 ± 5.34 years. It was noted that TGF-β1 gene expression level increased 2.91 times in the patient group compared to the control group (p = 0.03). TGF-β1 gene expression levels of patients with BAV decreased with age. This is the first study to show TGF-β1 gene expression levels in children with BAV. According to the results of our study, TGF-β1 gene expression levels in children with BAV decrease with age. Further studies are needed in all age groups to use TGF-β1 as a prognostic marker in patients with BAV.
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