ArticleNature computational science2024
An integrative data-driven model simulating C. elegans brain, body and environment interactions.
Article in Nature computational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Reductionism in Engram Neuroscience.The European journal of neuroscience · 2026Review
- The digital sphinx: Can a worm brain control a fly body?bioRxiv : the preprint server for biology · 2026Article
- From small brains to smart machines: translatingFrontiers in neural circuits · 2026Review
- Article
- A data-driven biology-based network model reproduces C. elegans premotor neural dynamics.PLoS computational biology · 2025Article
- CeDNe: A multi-scale computational framework for modeling structure-function relationships in thebioRxiv : the preprint server for biology · 2025Article
- An integrative data-driven model simulating C. elegans brain, body and environment interactions.Nature computational science · 2024Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The behavior of an organism is influenced by the complex interplay between its brain, body and environment. Existing data-driven models focus on either the brain or the body-environment. Here we present BAAIWorm, an integrative data-driven model of Caenorhabditis elegans, which consists of two submodels: the brain model and the body-environment model. The brain model was built by multicompartment models with realistic morphology, connectome and neural population dynamics based on experimental data. Simultaneously, the body-environment model used a lifelike body and a three-dimensional physical environment. Through the closed-loop interaction between the two submodels, BAAIWorm reproduced the realistic zigzag movement toward attractors observed in C. elegans. Leveraging this model, we investigated the impact of neural system structure on both neural activities and behaviors. Consequently, BAAIWorm can enhance our understanding of how the brain controls the body to interact with its surrounding environment.
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Registered trials
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