Evidence map›Paper›PMID 39681613›Full record

ArticleScientific reports2024

Cardiac biomarkers for detection of coronary artery disease in the community.

Lars Lind, Joakim Alfredsson, Jonas S O Andersson, Therese Andersson, Göran Bergström, Örjan Ekblom, Erika Fagman, Tove Fall, Emil Hagström, Hannes Holm Isholth and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Lars LindDepartment of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, SE 751 85, Sweden. lars.lind@medsci.uu.se.
Joakim AlfredssonDepartment of Cardiology, Department of Health, Medicine and Caring Sciences, Unit of Cardiovascular Sciences, Linköping University, Linköping, Sweden.
Jonas S O AnderssonDepartment of Public Health and Clinical Medicine, Skellefteå Research Unit, Umeå University, Umeå, Sweden.
Therese AnderssonDepartment of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden.
Göran BergströmDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Örjan EkblomDepartment of Physical Activity and Health, The Swedish School of Sport and Health Sciences (GIH), Stockholm, Sweden.
Erika FagmanRegion Västra Götaland, Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Tove FallDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
Emil HagströmDepartment of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Hannes Holm IsholthDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Magnus JanzonDepartment of Cardiology, Department of Health, Medicine and Caring Sciences, Unit of Cardiovascular Sciences, Linköping University, Linköping, Sweden.
Tomas JernbergDepartmentof Clinical Sciences, Danderyd University Hospital, Karolinska Institute, Stockholm, Sweden.
Ioannis KatsoularisDepartment of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden.
Karin LeanderUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Margrét LeósdóttirDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Martin MagnussonDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Andrei MalinovschiDepartment of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.
Annika RosengrenDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
J GustavSmithDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jonas SpaakDepartmentof Clinical Sciences, Danderyd University Hospital, Karolinska Institute, Stockholm, Sweden.
Per SvenssonDepartment of Clinical Science and Education, Karolinska Institute, Södersjukhuset, Stockholm, Sweden.
Stefan SöderbergDepartment of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden.
Carl Johan ÖstgrenCMIV Centre of Medical Image Science and Visualization, Linköping University, Linköping, Sweden.
Gunnar EngströmDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate whether coronary artery disease (CAD) burden is associated with plasma levels of the myocardial biomarkers Troponin I (TropI) and NT-proBNP in a large population-based sample using a cross-sectional design. Coronary computerized tomography (CT) angiography was performed in 25,859 subjects without a history of atherosclerotic disease from SCAPIS study (age 50-65, 52% women). TropI and NT-proBNP were measured in plasma. Segment involvement score (SIS) was the primary exposure and TropI the primary outcome. Both SIS and coronary artery calcium score, were associated with TropI levels following adjustment for age, sex and multiple confounders (p < 0.001), with similar relationships in men and women. Proximal segments from all three coronary arteries were related to TropI levels independently of one another. Adding TropI to traditional risk factors marginally increased discrimination of atherosclerosis as compared to risk factors alone (C-statistics + 0.0005, p = 0.014). SIS was related also to NT-proBNP levels, mainly in men, but with lower estimates than TropI. The burden of CAD was related to TropI levels in both men and women. All three major coronary arteries contributed to this relationship. Adding TropI to traditional risk factors resulted in only marginally improved discrimination of coronary atherosclerosis.

Indexed as

BiomarkersCoronary Artery DiseaseNatriuretic Peptide, BrainPeptide FragmentsTroponin IAgedComputed Tomography AngiographyCoronary AngiographyCoronary VesselsCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk FactorsBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Troponin ICoronary atherosclerosisEpidemiologyNT-proBNPPopulationTroponin

Identifiers

PMID39681613
PMCPMC11649811

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.