Evidence map›Paper›PMID 39681564›Full record

ArticleScientific reports2024

Perceived and endocrine acute and chronic stress indicators in fibromyalgia syndrome.

Eva Beiner, Michelle Hermes, Julian Reichert, Kristian Kleinke, Stephanie Vock, Annette Löffler, Leonie Ader, Andrei Sirazitdinov, Sebastian Keil, Tim Schmidt and 10 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Eva BeinerDepartment of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg, Germany.
Michelle HermesDepartment of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg, Germany.
Julian ReichertDepartment of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg, Germany.
Kristian KleinkeDepartment of Psychology, University of Siegen, Siegen, Germany.
Stephanie VockDepartment of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg, Germany.
Annette LöfflerInstitute of Cognitive and Clinical Neuroscience, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Leonie AderDepartment of Public Mental Health, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Andrei SirazitdinovData Analysis and Modeling in Medicine, Mannheim Institute for Intelligent Systems in Medicine (MIISM), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Sebastian KeilInstitute of Cognitive and Clinical Neuroscience, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Tim SchmidtDepartment of Public Mental Health, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Anita SchickDepartment of Public Mental Health, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Martin LöfflerInstitute of Cognitive and Clinical Neuroscience, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Michael HoppInterdisciplinary Center for Clinical Trials, Johannes Gutenberg University Medical Center Mainz, Mainz, Germany.
Christian RuckesInterdisciplinary Center for Clinical Trials, Johannes Gutenberg University Medical Center Mainz, Mainz, Germany.
Jürgen HesserData Analysis and Modeling in Medicine, Mannheim Institute for Intelligent Systems in Medicine (MIISM), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Ulrich ReininghausDepartment of Public Mental Health, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Wolfgang EichDepartment of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg, Germany.
Hans-Christoph FriederichDepartment of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg, Germany.
Jonas TesarzDepartment of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg, Germany. jonas.tesarz@med.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibromyalgia syndrome (FMS) is a chronic disorder characterized by widespread musculoskeletal pain, fatigue and tenderness and closely associated with high levels of stress. FMS is therefore often considered a stress-related disease. A comparative study was conducted with 99 individuals diagnosed with FMS and a control group of 50 pain-free individuals. Stress indicators were classified into three categories: perceived stress assessed using the Perceived Stress Scale, and daily average salivary cortisol and hair cortisol concentrations as indicators of acute and chronic stress levels related to the hypothalamic-pituitary-adrenal axis. Analysis of variance and covariance were used to identify group differences and the influence of covariates age, sex, and body mass index. Correlational analyses further elucidated the relationship between stress indicators and clinical symptoms. Participants with FMS reported significantly higher perceived stress levels than controls (p < .001, η

Indexed as

FibromyalgiaHairHydrocortisoneSalivaStress, PsychologicalAdultCase-Control StudiesFemaleHumansHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemHydrocortisoneEndocrine stress indicatorsFibromyalgia SyndromePerceived stress

Identifiers

PMID39681564
PMCPMC11649902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.