ArticleNature communications2024
A critical role of action-related functional networks in Gilles de la Tourette syndrome.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Secondary obsessive-compulsive syndromes: a systematic literature review resulting in 228 suspected cases.Molecular psychiatry · 2026Pooled it
- Tourette syndrome.Nature reviews. Disease primers · 2026Review
- Parietal signatures of urge control in paediatric tic disorders: Hyperactivation and salience-biased coupling.European child & adolescent psychiatry · 2026Article
- Circuit response to neuromodulation characterized with simultaneous deep brain stimulation and precision neuroimaging in humans.Nature neuroscience · 2026Article
- Article
- Beyond the Homunculus-SCAN-AMN as a Shared Action-Oriented Neural Substrate across Movement Disorders.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Local Field Potentials in Movement Disorders: A Narrative Review.Stereotactic and functional neurosurgery · 2026Review
- [Update on tic disorders and Tourette syndrome].Der Nervenarzt · 2025Review
- Somato-Cognitive Action Network in Focal Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- The Neuropsychology of Chronic Neurological Disorders: A Review of Cognitive and Emotional Impairments.Cureus · 2025Review
- Action-mode subnetworks for decision-making, action control, and feedback.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Engaging dystonia networks with subthalamic stimulation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Alterations of sensorimotor predictive processes and their electrophysiological signatures in Tourette syndrome.Brain communications · 2025Article
- Resting-state fMRI dynamic functional network in young children with Tourette syndrome.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
26 authors.
Funding
Abstract
Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing tic severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep brain stimulation (DBS) cohorts and a cohort of tic-inducing lesions to infer critical networks for treatment and occurrence of tics by mapping stimulation sites and lesions to a functional connectome derived from 1,000 healthy participants. We find that greater tic reduction is linked to higher connectivity of DBS sites (N = 37) with action-related functional resting-state networks, i.e., the cingulo-opercular (r = 0.62; p < 0.001) and somato-cognitive action networks (r = 0.47; p = 0.002). Regions of the cingulo-opercular network best match the optimal connectivity profiles of thalamic DBS. We replicate the significance of targeting cingulo-opercular and somato-cognitive action network connectivity in an independent DBS cohort (N = 10). Finally, we demonstrate that tic-inducing brain lesions (N = 22) exhibit similar connectivity to these networks. Collectively, these results suggest a critical role for these action-related networks in the pathophysiology and treatment of GTS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.