Molecular Imaging of Tumor-Infiltrating Lymphocytes in Living Animals Using a Novel mCD3 Fibronectin Scaffold.

Char Wynter, Arutselvan Natarajan, Clyde John, Kaahini Jain, Ramasamy Paulmurugan

Abstract read

In one paragraph

Article in Bioconjugate chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Char WynterCanary Center for Cancer Early Detection, Department of Radiology, Stanford University, Palo Alto, California 94304, United States.

Arutselvan NatarajanCanary Center for Cancer Early Detection, Department of Radiology, Stanford University, Palo Alto, California 94304, United States.ORCID 0000-0002-9958-2623

Clyde JohnCanary Center for Cancer Early Detection, Department of Radiology, Stanford University, Palo Alto, California 94304, United States.

Kaahini JainCanary Center for Cancer Early Detection, Department of Radiology, Stanford University, Palo Alto, California 94304, United States.

Ramasamy PaulmuruganCanary Center for Cancer Early Detection, Department of Radiology, Stanford University, Palo Alto, California 94304, United States.ORCID 0000-0001-7155-4738

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI MICHAEL KENNEY · 2007 to 2026

$71.4M

NCI NIH HHS P30 CA124435

6 · The paper itself

Abstract

The interaction between cancer cells and immune cells in the tumor microenvironment (TME) plays a crucial role in determining tumor growth, metastasis, and response to treatment. Tumor-infiltrating lymphocytes (TILs) in TME could be a predictive marker for treatment response in various therapeutic interventions, including chemotherapy and immunotherapy. Thus, imaging the tumor immune microenvironment is important for selecting the optimal treatment strategies in cancer therapy. The CD3 protein represents a promising target for diagnostic imaging of TILs

Indexed as

FibronectinsLymphocytes, Tumor-InfiltratingMolecular ImagingAnimalsCD3 ComplexCell Line, TumorFemaleHumansMiceMice, Inbred C57BLTumor MicroenvironmentCD3 ComplexFibronectins

Identifiers

PMID39681342

DOI10.1021/acs.bioconjchem.4c00501

PMCPMC12990151

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.