Evidence map›Paper›PMID 39680853›Full record

ArticleBiochemistry2025

Cryo-EM Structure of Recombinantly Expressed hUGDH Unveils a Hidden, Alternative Allosteric Inhibitor.

John H O'Brien, Renuka Kadirvelraj, Po-Sen Tseng, Nolan Ross-Kemppinen, David Crich, Richard M Walsh, Zachary A Wood

Abstract read
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

John H O'BrienDepartment of Biochemistry & Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-4021-376X
Renuka KadirvelrajDepartment of Biochemistry & Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.
Po-Sen TsengDepartment of Pharmaceutical and Biomedical Sciences, Department of Chemistry, and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0003-2860-5725
Nolan Ross-KemppinenDepartment of Biochemistry & Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0003-1613-8752
David CrichDepartment of Pharmaceutical and Biomedical Sciences, Department of Chemistry, and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0003-2400-0083
Richard M WalshDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, United States.ORCID 0000-0002-8939-8988
Zachary A WoodDepartment of Biochemistry & Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-7251-0822

Funding

The role of intrinsic disorder in the allosteric regulation of human UGDHR01GM114298 · NIGMS · UNIVERSITY OF GEORGIA · PI WOOD, ZACHARY ARTHUR · 2015 to 2025
$2.7M
NIGMS NIH HHS R01 GM114298
6 · The paper itself

Abstract

Human UDP-glucose dehydrogenase (hUGDH) catalyzes the oxidation of UDP-glucose into UDP-glucuronic acid, an essential substrate in the Phase II metabolism of drugs. hUGDH is a hexamer that exists in an equilibrium between an active (E) state and an inactive (E

Indexed as

Cryoelectron MicroscopyRecombinant ProteinsUridine Diphosphate Glucose DehydrogenaseAllosteric RegulationEnzyme InhibitorsEscherichia coliHumansModels, MolecularProtein ConformationUridine Diphosphate XyloseEnzyme InhibitorsRecombinant ProteinsUridine Diphosphate Glucose DehydrogenaseUridine Diphosphate Xylose

Identifiers

PMID39680853
PMCPMC11713868

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.