Evidence map›Paper›PMID 39680824›Full record

ArticleJCO oncology practice2025

Portable Medical Orders and Inpatient Cost at End of Life in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

Marissa LoCastro, Andrea Baran, Jane Liesveld, Eric Huselton, Elaine Hill, Kah Poh Loh, Jason H Mendler

Abstract read
In one paragraph

Article in JCO oncology practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marissa LoCastroSchool of Medicine and Dentistry, University of Rochester, Rochester, NY.ORCID 0000-0002-1075-8443
Andrea BaranDivision of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.ORCID 0000-0002-7975-8919
Jane LiesveldDivision of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.ORCID 0000-0002-3386-8469
Eric HuseltonDivision of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.
Elaine HillDepartment of Public Health Sciences, University of Rochester Medical Center, Rochester, NY.ORCID 0000-0003-2494-317X
Kah Poh LohDivision of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.ORCID 0000-0002-6978-0418
Jason H MendlerDivision of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.ORCID 0000-0001-5605-5324

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
NRSA Training CoreTL1TR002000 · NCATS · UNIVERSITY OF ROCHESTER · PI THAKAR, JUILEE, VAN WIJNGAARDEN, EDWIN · 2016 to 2024
$4.1M
A novel mobile health exercise intervention for older patients with myeloid neoplasmsR00CA237744 · NCI · UNIVERSITY OF ROCHESTER · PI LOH, KAH POH · 2021 to 2023
$747k
A Novel Mobile Health Exercise Intervention for Older Patients with Myeloid NeoplasmsK99CA237744 · NCI · UNIVERSITY OF ROCHESTER · PI LOH, KAH POH · 2019 to 2020
$385k
NCATS NIH HHS TL1 TR002000NCI NIH HHS K99 CA237744NCI NIH HHS R00 CA237744NCI NIH HHS UG1 CA189961
6 · The paper itself

Abstract

purposeWe previously demonstrated that early completion of portable medical orders, known as Medical Orders for Life-Sustaining Treatment (MOLST), was associated with lower-intensity care at the end of life (EOL) for patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The purpose of this study was to investigate the impact of a MOLST form completed before hospitalization on the cost of inpatient care during the last 30 days of life for patients with AML and MDS.

methodsWe conducted a retrospective study of 271 adult patients with a diagnosis of AML or MDS who died between January 1, 2014, and December 31, 2019, and received care for their hematologic malignancy at the University of Rochester Medical Center (URMC). Costs were hospital charges for inpatient care at URMC. Nonparametric Wilcoxon rank-sum tests were used to compare costs between diagnosis and age subgroups (AML

resultsAmong patients hospitalized within the last 30 days of life (n = 229), the median cost of inpatient care within the last 30 days of life was $24,054 in US dollars (USD). Median cost was lower for patients who completed a MOLST form before hospitalization than for patients who had not ($17,808

conclusionCompletion of a MOLST form before hospitalization was associated with lower inpatient costs at EOL for patients with AML and MDS.

Indexed as

HospitalizationLeukemia, Myeloid, AcuteMyelodysplastic SyndromesTerminal CareAdultAgedAged, 80 and overFemaleHumansInpatientsMaleMiddle AgedRetrospective Studies

Identifiers

PMID39680824
PMCPMC12162244

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.