Evidence map›Paper›PMID 39680623›Full record

ArticleJournal of medicinal chemistry2025

Guardians at the Gate: Optimization of Small Molecule Entry Inhibitors of Ebola and Marburg Viruses.

Malaika D Argade, Jazmin Galván Achi, Ryan Bott, Kimberly M Morsheimer, Callum D Owen, Christian A Zielinski, Arsen M Gaisin, Mario Alvarez, Terry W Moore, Fan Bu and 7 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Malaika D ArgadeUICentre: Drug Discovery, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-3401-1598
Jazmin Galván AchiDepartment of Microbiology and Immunology, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-6177-0397
Ryan BottDepartment of Microbiology and Immunology, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Kimberly M MorsheimerDepartment of Virology, Immunology, and Microbiology, National Emerging Infectious Diseases Laboratories, Boston University Medical Campus, Boston, Massachusetts 02118, United States.ORCID 0009-0004-5919-6746
Callum D OwenDepartment of Virology, Immunology, and Microbiology, National Emerging Infectious Diseases Laboratories, Boston University Medical Campus, Boston, Massachusetts 02118, United States.ORCID 0009-0000-9972-1745
Christian A ZielinskiUICentre: Drug Discovery, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Arsen M GaisinUICentre: Drug Discovery, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Mario AlvarezDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Terry W MooreDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-5410-306X
Fan BuDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, United States.
Fang LiDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, United States.
Michael CameronDepartment of Molecular Medicine, Herbert Wertheim, UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, Florida 33458, United States.ORCID 0000-0003-3154-4775
Manu AnantpadmaThe Integrated Research Facility, National Institute of Allergy and Infectious Diseases, Frederick, Maryland 20892, United States.
Robert A DaveyDepartment of Virology, Immunology, and Microbiology, National Emerging Infectious Diseases Laboratories, Boston University Medical Campus, Boston, Massachusetts 02118, United States.ORCID 0000-0001-9168-2892
Norton P PeetChicago BioSolutions Inc., Chicago, Illinois 60612, United States.
Lijun RongDepartment of Microbiology and Immunology, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Irina N GaisinaUICentre: Drug Discovery, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-8668-3222

Funding

Project 5: Pandemic Virus Helicase InhibitorsU19AI171954 · NIAID · UNIVERSITY OF MINNESOTA · PI Donghoon Chung · 2022 to 2026
$100.9M
4-(Aminomethyl) benzamides as novel anti-Ebola agentsR42AI126971 · NIAID · CHICAGO BIOSOLUTIONS, INC. · PI RONG, LIJUN · 2019 to 2021
$2.9M
Sciex 6500+ QTrap Mass SpectrometerS10OD030332 · OD · SCRIPPS FLORIDA · PI CAMERON, MICHAEL DARIN · 2021 to 2021
$486k
NIAID NIH HHS HHSN272201800013CNIAID NIH HHS R42 AI126971NIAID NIH HHS U19 AI171954NIH HHS S10 OD030332
6 · The paper itself

Abstract

Ebola and Marburg (EBOV and MARV) filoviral infections lead to fatal hemorrhagic fevers and have caused over 30 outbreaks in the last 50 years. Currently, there are no FDA-approved small molecule therapeutics for effectively treating filoviral diseases. To address this unmet medical need, we have conducted a systematic structural optimization of an early lead compound,

Indexed as

Antiviral AgentsEbolavirusMarburgvirusAnimalsBenzamidesHumansMarburg Virus DiseaseSmall Molecule LibrariesStructure-Activity RelationshipVirus InternalizationAntiviral AgentsBenzamidesSmall Molecule Libraries

Identifiers

PMID39680623
PMCPMC12381577

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.