Evidence map›Paper›PMID 39680577›Full record

ArticleJournal of the American Chemical Society2025

Photoswitchable Diazocine Derivative for Adenosine A

Marc López-Cano, Mirko Scortichini, Dilip K Tosh, Veronica Salmaso, Tongil Ko, Glòria Salort, Ingrid Filgaira, Concepció Soler, Dirk Trauner, Jordi Hernando and 2 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Bitopic AJournal of medicinal chemistry · 2025
    Article
  6. Article
  7. Synthesis and Characterization of Photoswitchable Covalent Ligands for the βAngewandte Chemie (International ed. in English) · 2025
    Article
  8. Reversible phase transition in 8,19-dimethyl-2,3,8,19-tetra-aza-penta-cyclo[13.7.0.0Acta crystallographica. Section E, Crystallographic communications · 2025
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marc López-CanoPharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat 08907, Spain.
Mirko ScortichiniMolecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, United States.
Dilip K ToshMolecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, United States.
Veronica SalmasoMolecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, United States.
Tongil KoDepartment of Chemistry, University of Pennsylvania College of Arts and Sciences, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-3070-9243
Glòria SalortPharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat 08907, Spain.
Ingrid FilgairaImmunology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, University of Barcelona, L'Hospitalet de Llobregat 08907, Spain.ORCID 0000-0002-9886-3925
Concepció SolerImmunology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, University of Barcelona, L'Hospitalet de Llobregat 08907, Spain.
Dirk TraunerDepartment of Chemistry, University of Pennsylvania College of Arts and Sciences, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-6782-6056
Jordi HernandoDepartment of Chemistry, Autonomous University of Barcelona, Cerdanyola del Vallès 08193, Spain.ORCID 0000-0002-1126-4138
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0001-8104-1493
Francisco CiruelaPharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat 08907, Spain.ORCID 0000-0003-0832-3739

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Intramural NIH HHS ZIA DK031117
6 · The paper itself

Abstract

Incorporating photoisomerizable moieties within drugs offers the possibility of rapid and reversible light-dependent switching between active and inactive configurations. Here, we developed a photoswitchable adenosine A

Indexed as

Adenosine A3 Receptor AgonistsPsoriasisAnimalsHumansMiceMolecular StructurePhotochemical ProcessesReceptor, Adenosine A3Adenosine A3 Receptor AgonistsReceptor, Adenosine A3

Identifiers

PMID39680577
PMCPMC11726555

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.