Evidence map›Paper›PMID 39680434›Full record

ArticleeLife2024

Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50.

Eyal Paz, Sahil Jain, Irit Gottfried, Orna Staretz-Chacham, Muhammad Mahajnah, Pritha Bagchi, Nicholas T Seyfried, Uri Ashery, Abdussalam Azem

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Eyal Paz *School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID https://orcid.org/0009-0009-3674-956X
Sahil Jain *School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID https://orcid.org/0000-0003-3799-2421
Irit GottfriedSchool of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Orna Staretz-ChachamMetabolic Disease Unit, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel.
Muhammad MahajnahThe Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Pritha BagchiCenter for Neurodegenerative Diseases, Emory University, Atlanta, United States.
Nicholas T SeyfriedCenter for Neurodegenerative Diseases, Emory University, Atlanta, United States.
Uri AsherySchool of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Abdussalam AzemSchool of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID https://orcid.org/0000-0002-2288-2986

Funding

Serotonergic IL-1R1 and Neuropsychiatric Traits of an Alzheimer's Mouse ModelR21AG074846 · NIA · FLORIDA ATLANTIC UNIVERSITY · PI ASHERY, URI, BLAKELY, RANDY D. · 2022 to 2022
$379k
BrightFocus Foundation A2022029SIsrael Science Foundation 1057/22Israel Science Foundation 1389/18Israel Science Foundation 2141/20Michael J. Fox Foundation for Parkinson's Research MJFF-022407Ministry of Innovation, Science and Technology 1001576154NIA NIH HHS R21 AG074846NIH Blueprint for Neuroscience Research 1R21AG074846-01A1
6 · The paper itself

Abstract

TIMM50, an essential TIM23 complex subunit, is suggested to facilitate the import of ~60% of the mitochondrial proteome. In this study, we characterized a

Indexed as

FibroblastsMitochondriaMitochondrial Precursor Protein Import Complex ProteinsNeuronsAnimalsHumansMembrane Transport ProteinsMiceMitochondrial Membrane Transport ProteinsMitochondrial ProteinsMutationMembrane Transport ProteinsMitochondrial Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsMitochondrial ProteinsTIMM50 protein, humanAction potentialbiochemistrychemical biologyhumanimport diseasemitochondriamitochondrial protein importmouseneuroscienceTIM23TIMM50TIMM50 disease

Identifiers

PMID39680434
PMCPMC11649234

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.