Evidence map›Paper›PMID 39680336›Full record

ArticleGlycoconjugate journal2024

Inhibition of sulfated glycans on the binding of dengue virus envelope protein to heparin.

Jiyuan Yang, Payel Datta, Ke Xia, Vitor H Pomin, Chunyu Wang, Mingqiang Qiao, Robert J Linhardt, Jonathan S Dordick, Fuming Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glycoconjugate journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiyuan YangThe Key Laboratory of Molecular Microbiology and Technology, College of Life Sciences, Ministry of Education, Nankai University, Tianjin, 300071, P.R. China.
Payel DattaDepartment of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Ke XiaDepartment of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Vitor H PominDepartment of BioMolecular Sciences, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA.
Chunyu WangDepartment of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Mingqiang QiaoThe Key Laboratory of Molecular Microbiology and Technology, College of Life Sciences, Ministry of Education, Nankai University, Tianjin, 300071, P.R. China.
Robert J LinhardtDepartment of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Jonathan S DordickDepartments of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA. dordick@rpi.edu.
Fuming ZhangDepartments of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA. zhangf2@rpi.edu.

Funding

Tracking Glycosylation State with Fluorinated Glycosides ProbesP20GM130460 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Joshua S Sharp · 2020 to 2026
$17.9M
ApoE and Heparan Sulfate Interaction in Alzheimer’s DiseaseR01AG087305 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI JIAN LIU, Chunyu Wang · 2024 to 2026
$2.3M
Orbitrap Eclipse Tribrid Mass Spectrometer as a Regional ResourceS10OD032168 · OD · RENSSELAER POLYTECHNIC INSTITUTE · PI ZHANG, FUMING · 2023 to 2023
$1.2M
Heparan Sulfate 3-O-Sulfation in Transcellular Propagation of Tauopathy in Alzheimer's DiseaseR01AG069039 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI LINHARDT, ROBERT J, LIU, JIAN · 2024 to 2024
$555k
Glycomics-driven diagnostics for Candida aurisR21AI156573 · NIAID · RENSSELAER POLYTECHNIC INSTITUTE · PI CHATURVEDI, VISHNU, ZHANG, FUMING · 2021 to 2022
$454k
Biacore T200 Surface Plasmon Resonance SpectroscopyS10OD028523 · OD · RENSSELAER POLYTECHNIC INSTITUTE · PI LINHARDT, ROBERT J · 2020 to 2020
$344k
Disruption of CS/KSPG-Mediated Neuronal Outgrowth InhibitionR03NS110996 · NINDS · UNIVERSITY OF MISSISSIPPI · PI POMIN, VITOR HUGO · 2020 to 2020
$142k
NIAID NIH HHS R21 AI156573NIA NIH HHS R01 AG069039NIA NIH HHS R01 AG087305NIGMS NIH HHS P20 GM130460NIH HHS NIH [S10OD028523 and R21AI156573 (R.J.L, F.Z.), 1P20GM130460-01A1-7936 and 1R03NS110996-01A1, R01 AG069039-01NIH HHS S10 OD028523NIH HHS S10 OD032168NINDS NIH HHS R03 NS110996
6 · The paper itself

Abstract

Dengue viruses (DENV) are transmitted to humans through mosquito bites and infect millions globally. DENV uses heparan sulfate (HS) for attachment and cell entry by binding the envelope protein to highly sulfated HS on target cells. Therefore, inhibiting the binding between DENV and HS could be a promising strategy for preventing DENV infection. In the current study, the interactions between DENV envelope protein (from Type 2 DENV) and heparin (a surrogate for HS) were analyzed using competition solution SPR. Results demonstrate that heparin binds to DENV envelope protein with high affinity (K

Indexed as

Dengue VirusHeparinPolysaccharidesViral Envelope ProteinsHeparan SulfateHumansProtein BindingHeparan SulfateHeparinPolysaccharidesViral Envelope ProteinsDengue virusHeparinMarine Sourced glycansSulfated glycansSurface plasmon resonance

Identifiers

PMID39680336
PMCPMC12168185

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.