Evidence map›Paper›PMID 39680318›Full record

ReviewCurrent topics in behavioral neurosciences2025

Fear and Anxiety in Schizophrenia: A Focus on Development, Assessment, and Mechanisms.

Brandee Feola, Marren Jenkins, Julia M Sheffield, Jennifer Urbano Blackford

Abstract readReview
In one paragraph

Review in Current topics in behavioral neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brandee FeolaDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. brandee.feola@vumc.org.
Marren JenkinsDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Julia M SheffieldDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Jennifer Urbano BlackfordMunroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, NE, USA.

Funding

Negative Valence Systems in SchizophreniaR01MH127018 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FEOLA, BRANDEE, WOODWARD, NEIL D. · 2021 to 2025
$3.3M
Testing the role of belief updating in persecutory delusionsR01MH137024 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julia May Sheffield · 2024 to 2026
$2.3M
Cognitive mechanisms of delusion severity throughout recovery from a psychotic episode: a computational approachK23MH126313 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHEFFIELD, JULIA MAY · 2021 to 2025
$821k
NIMH NIH HHS K23 MH126313NIMH NIH HHS R01 MH127018NIMH NIH HHS R01 MH137024
6 · The paper itself

Abstract

In people with schizophrenia, anxiety is highly prevalent and related to numerous negative outcomes; unfortunately, anxiety is both underreported and understudied in schizophrenia. The current review highlights the importance and utility of assessing anxiety in schizophrenia by addressing four main questions: (1) What does anxiety look like throughout the development of schizophrenia?; (2) How do we measure anxiety in schizophrenia?; (3) What are the mechanisms underlying anxiety in schizophrenia; (4) How do we treat anxiety in schizophrenia? We also provide take-home points and propose future directions for the field. We hope this emphasis on the critical role of anxiety in schizophrenia will help researchers appropriately identify the presence of anxiety, better address these symptoms, and improve the lives of people at risk for or experiencing psychosis.

Indexed as

AnxietyFearSchizophreniaSchizophrenic PsychologyHumansAnxiety disordersNegative affectNegative emotionPsychosisSchizophrenia spectrum disorders

Identifiers

PMID39680318
PMCPMC12170919

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.