Evidence map›Paper›PMID 39680245›Full record

ArticleMolecular biology reports2024

Molecular insights into Wnt3a and Wnt5a gene expression in venous insufficiency.

Fatima Eltayb M Ageed, Fadumo Ali Tifow, Leylo Abdullahi Ibrahim, Aya B Ismael, Özlem Balcıoğlu, Barçın Özcem, Havva Cobanogullari, Selma Yılmaz, Mahmut Çerkez Ergören

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Fatima Eltayb M AgeedFaculty of Medicine, Department of Medical Genetics, Near East University, Nicosia, 99138, Cyprus.
Fadumo Ali TifowFaculty of Medicine, Department of Medical Genetics, Near East University, Nicosia, 99138, Cyprus.
Leylo Abdullahi IbrahimFaculty of Medicine, Department of Medical Genetics, Near East University, Nicosia, 99138, Cyprus.
Aya B IsmaelFaculty of Medicine, Department of Medical Genetics, Near East University, Nicosia, 99138, Cyprus.
Özlem BalcıoğluFaculty of Medicine, Department of Cardiovascular Surgery, Near East University, Nicosia, 99138, Cyprus.
Barçın ÖzcemFaculty of Medicine, Department of Cardiovascular Surgery, Near East University, Nicosia, 99138, Cyprus.
Havva CobanogullariLaboratory of Medical Genetics, Near East University, Near East University Hospital, Nicosia, 99138, Cyprus.
Selma YılmazFaculty of Medicine, Department of Medical Genetics, Near East University, Nicosia, 99138, Cyprus.
Mahmut Çerkez ErgörenFaculty of Medicine, Department of Medical Genetics, Near East University, Nicosia, 99138, Cyprus. mahmutcerkez.ergoren@neu.edu.tr.ORCID http://orcid.org/0000-0001-9593-9325

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic venous insufficiency (CVI) manifests as morphological and functional abnormalities in the venous system, primarily affecting the lower extremities and presenting as leg heaviness, oedema, and varicose veins. CVI is a common vascular disorder characterised by impaired blood flow in the veins, often leading to various clinical manifestations. To better understand the additional underlying mechanisms of CVI, it is essential to explore the role of Wnt proteins, which play a crucial role in regulating signalling processes. This study aimed to investigate the expression levels of the Wnt3a and Wnt5a genes using real-time PCR in patients with venous insufficiency compared to acontrol group. METHODS AND

results68 participants were included, comprising 29 controls and 39 patients with venous insufficiency from Near East University Hospital. Real-time PCR was utilised for gene expression analysis on a segment of the great saphenous vein biopsy, encompassing all vascular layers, from each participant in both groups. With a significance threshold of p < 0.05, the analysis revealed a significant difference in Wnt3a gene expression (p ₌ 0.0007) and a nonsignificant difference in Wnt5a expression levels (p ₌ 0.5726) between patients with venous insufficiency and the healthy control group.

conclusionThis study indicates fluctuations in the Wnt genes in varicose vein biopsies compared to healthy veins. Consequently, further research is essential to elucidate whether the dysregulation of the Wnt pathway induces venous insufficiency or vice versa. This may facilitate targeted interventions addressing its fundamental molecular aberrations.

Indexed as

Venous InsufficiencyWnt3A ProteinWnt-5a ProteinAdultAgedCase-Control StudiesFemaleGene ExpressionGene Expression RegulationHumansMaleMiddle AgedSaphenous VeinVaricose VeinsWnt3A ProteinWNT3A protein, humanWnt-5a ProteinWNT5A protein, humanGene expressionVaricose veinsVenous insufficiencywnt3awnt5a

Identifiers

PMID39680245

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.