Evidence map›Paper›PMID 39680136›Full record

ArticleCellular and molecular life sciences : CMLS2024

Golgi pH elevation due to loss of V-ATPase subunit V0a2 function correlates with tissue-specific glycosylation changes and globozoospermia.

Johannes Kopp, Denise Jahn, Guido Vogt, Anthi Psoma, Edoardo Ratto, Willy Morelle, Nina Stelzer, Ingrid Hausser, Anne Hoffmann, Miguel Rodriguez de Los Santos and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Abnormal von Willebrand factor multimer pattern withoutBlood vessels, thrombosis & hemostasis · 2026
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Johannes Kopp *Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Institute of Medical Genetics and Human Genetics, 13353, Berlin, Germany.ORCID https://orcid.org/0000-0002-0391-1497
Denise Jahn *Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Institute of Medical Genetics and Human Genetics, 13353, Berlin, Germany.ORCID https://orcid.org/0000-0001-8912-5851
Guido Vogt *Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Institute of Medical Genetics and Human Genetics, 13353, Berlin, Germany.ORCID https://orcid.org/0000-0002-7475-2972
Anthi PsomaDepartment of Molecular Immunology (MI), University of Groningen, 9747AG, Groningen, The Netherlands.ORCID https://orcid.org/0009-0009-9034-4440
Edoardo RattoCell Signaling and Metabolism, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-4104-7556
Willy MorelleUniversity of Lille, CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, 59000, Lille, France.ORCID https://orcid.org/0009-0004-8330-4049
Nina StelzerCharité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Institute of Medical Genetics and Human Genetics, 13353, Berlin, Germany.ORCID https://orcid.org/0000-0001-9822-5694
Ingrid HausserInstitute of Pathology, Heidelberg University Hospital, 69120, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-1095-4962
Anne HoffmannCharité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Institute of Medical Genetics and Human Genetics, 13353, Berlin, Germany.ORCID https://orcid.org/0009-0004-7638-5602
Miguel Rodriguez de Los SantosCharité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Institute of Medical Genetics and Human Genetics, 13353, Berlin, Germany.ORCID https://orcid.org/0000-0002-2126-7658
Leonard A KochCharité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Institute of Medical Genetics and Human Genetics, 13353, Berlin, Germany.ORCID https://orcid.org/0000-0003-4943-198X
Björn Fischer-ZirnsakCharité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Institute of Medical Genetics and Human Genetics, 13353, Berlin, Germany.ORCID https://orcid.org/0000-0002-1075-7571
Christian ThielCentre for Child and Adolescent Medicine, Department I, University Hospital Heidelberg, 69115, Heidelberg, Germany.ORCID https://orcid.org/0000-0001-6419-8747
Wilhelm PalmCell Signaling and Metabolism, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.ORCID https://orcid.org/0000-0003-0612-770X
David MeierhoferMax Planck Institute for Molecular Genetics, Mass-Spectrometry Facility, 14195, Berlin, Germany.ORCID https://orcid.org/0000-0002-0170-868X
Geert van den BogaartDepartment of Molecular Immunology (MI), University of Groningen, 9747AG, Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-2180-6735
François FoulquierUniversity of Lille, CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, 59000, Lille, France.ORCID https://orcid.org/0000-0001-5084-4015
Andreas MeinhardtInstitute of Anatomy and Cell Biology, Justus-Liebig-Universität Gießen, 35385, Gießen, Germany.ORCID https://orcid.org/0000-0003-3711-2746
Uwe KornakInstitute of Human Genetics, University Medical Center Göttingen, 37073, Göttingen, Germany. uwe.kornak@med.uni-goettingen.de.ORCID http://orcid.org/0000-0002-4582-9838

Funding

Horizon 2020 Framework Programme Cofund action FWO GOI2918N; EUROGLYCAN-omicsHorizon 2020 Framework Programme Cofund action N° 643578; EURO-CDG-2Horizon 2020 Framework Programme FWO GOI2918N; EUROGLYCAN-omicsSeventh Framework Programme ERARE11-135Seventh Framework Programme EURO-CDG
6 · The paper itself

Abstract

Loss-of-function variants in ATP6V0A2, encoding the trans Golgi V-ATPase subunit V0a2, cause wrinkly skin syndrome (WSS), a connective tissue disorder with glycosylation defects and aberrant cortical neuron migration. We used knock-out (Atp6v0a2

Indexed as

Golgi ApparatusVacuolar Proton-Translocating ATPasesAnimalsFibroblastsGlycosylationHumansHydrogen-Ion ConcentrationMaleMiceMice, Inbred C57BLMice, KnockoutTeratozoospermiaVacuolar Proton-Translocating ATPasesCutis laxaGlobozoospermiaGlycosylationGolgiNeuronal migrationpH-regulationSpermiogenesisV-ATPaseVesicular trafficking

Identifiers

PMID39680136
PMCPMC11649611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.