Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Richard VanDepartment of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Pkwy, Norman, Oklahoma 73019, United States.
Xiaoliang PanDepartment of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Pkwy, Norman, Oklahoma 73019, United States.ORCID 0000-0002-6399-4853
Saadi RostamiDepartment of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Pkwy, Norman, Oklahoma 73019, United States.
Jin LiuDepartment of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas 76107, United States.ORCID 0000-0002-1067-4063
Pratul K AgarwalDepartment of Physiological Sciences and High Performance Computing Center, Oklahoma State University, 106 Math Sciences, Stillwater, Oklahoma 74078, United States.ORCID 0000-0002-3848-9492
Bernard BrooksLaboratory of Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0002-3586-2730
Rakhi RajanDepartment of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Pkwy, Norman, Oklahoma 73019, United States.ORCID 0000-0002-8719-4412
Yihan ShaoDepartment of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Pkwy, Norman, Oklahoma 73019, United States.ORCID 0000-0001-9337-341X
Funding
Development Of Theoretical Methods For Studying Biological MacromoleculesZIAHL001051 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BROOKS, BERNARD R · 2009 to 2025
$16.2M
Protein Production and Characterization CoreP30GM145423 · NIGMS · UNIVERSITY OF OKLAHOMA · PI ANN H WEST · 2022 to 2026
$6.9M
Theoretical Methods to Study Biological MacromoleculesZ01HL001051 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BROOKS, BERNARD R · 1998 to 2008
$1.4M
Multiscale ab initio QM/MM and Machine Learning Methods for Accelerated Free Energy SimulationsR44GM133270 · NIGMS · Q-CHEM, INC. · PI FENG, XINTIAN · 2023 to 2024
$1.3M
Multiscale Modeling of Enzymatic Reactions and Bioimaging ProbesR35GM153297 · NIGMS · UNIVERSITY OF OKLAHOMA · PI Yihan Shao · 2024 to 2026
$1.1M
Multiscale Modeling of Enzymatic Reactions and Firefly BioluminescenceR01GM135392 · NIGMS · UNIVERSITY OF OKLAHOMA · PI SHAO, YIHAN · 2019 to 2022
$1.0M
Efficient double hybrid density functional theory algorithms for conformational aR44GM096678 · NIGMS · Q-CHEM, INC. · PI SHAO, YIHAN · 2014 to 2015
$937k
Biophysical Model of Enzyme Catalysis: Conformational sub-states, solvent coupling and energy networksR01GM148886 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI David Wayne Ussery · 2023 to 2026
$888k
De novo development of small CRISPR-Cas proteins using artificial intelligence algorithmsR21GM144860 · NIGMS · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI LIU, JIN · 2022 to 2023
The target DNA (tDNA) cleavage catalyzed by the CRISPR Cas9 enzyme is a critical step in the Cas9-based genome editing technologies. Previously, the tDNA cleavage from an active SpyCas9 enzyme conformation was modeled by Palermo and co-workers (Nierzwicki et al.,
Indexed as
CRISPR-Cas SystemsDNA CleavageQuantum TheoryCatalytic DomainCRISPR-Associated Protein 9DNAMolecular Dynamics SimulationThermodynamicsCRISPR-Associated Protein 9DNA
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Exploring CRISPR-Cas9 HNH-Domain-Catalyzed DNA Cleavage Using Accelerated Quantum Mechanical Molecular Mechanical Free Energy Simulation. · full record | OpenQuestion