Observational studyHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2025
Influence of occupational stress on breast cancer incidence in the Women's Health Initiative.
Observational study in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Mechanistic Exploration of Shugan Jianpi Formula for Treating Triple-Negative Breast Cancer Under Chronic Stress: A Network Pharmacology-Guided Experimental Study.Drug design, development and therapy · 2025Article
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9 authors.
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Abstract
objectivePsychological stress has long been posited as a potential risk factor for breast cancer. We aimed to examine the relationship between occupational stress and the incidence of invasive breast cancer among postmenopausal women from the Women's Health Initiative Observational Study.
methodOccupational stress was characterized through linkage of Standard Occupational Classification codes for participants' jobs to the Occupational Information Network. Following the Karasek job strain model, we cross-categorized demand and control and created four categories of occupational strain. Cox proportional hazards regression models were used to calculate hazard ratios and 95% confidence intervals (CIs).
resultsWomen with a history of high-strain work (high demand and low control) compared to low-strain work (low demand and high control) were 9% more likely to develop invasive breast cancer during follow-up (hazard ratios = 1.09; 95% CI [1.00, 1.19]) when controlling for age, race/ethnicity, geographical region, education, marital status, and familial history of breast cancer. This weak association between high-strain work and risk of breast cancer was rather consistent across analyses, but CIs included the null value in most models.
conclusionsOur results highlight the potential importance of the occupational domain as a source of stress for women and suggest a possible, but yet tenuous, role in chronic disease etiology. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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