Evidence map›Paper›PMID 39679919›Full record

ArticleeLife2024

Identification of an early subset of cerebellar nuclei neurons in mice.

Maryam Rahimi-Balaei, Shayan Amiri, Thomas Lamonerie, Sih-Rong Wu, Huda Y Zoghbi, G Giacomo Consalez, Daniel Goldowitz, Hassan Marzban

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maryam Rahimi-BalaeiDepartment of Human Anatomy and Cell Science, The Children's Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.ORCID https://orcid.org/0000-0002-1758-0908
Shayan AmiriDepartment of Human Anatomy and Cell Science, The Children's Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
Thomas LamonerieUniversité Côte d'Azur, CNRS, Inserm, iBV, Nice, France.
Sih-Rong WuUniversity of California, San Francisco (UCSF), San Francisco, United States.
Huda Y ZoghbiDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.ORCID https://orcid.org/0000-0002-0700-3349
G Giacomo ConsalezDivision of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0003-4594-6273
Daniel GoldowitzDepartment of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0003-4756-4017
Hassan MarzbanDepartment of Human Anatomy and Cell Science, The Children's Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.ORCID https://orcid.org/0000-0001-6885-2590

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2018-06040Research Manitoba Tri-Council Bridge Funding Program 47955The Children's Hospital Research Institute of Manitoba 320035
6 · The paper itself

Abstract

Cerebellar nuclei (CN) neurons serve as the primary output of the cerebellum and originate from the cerebellar primordium at early stages of cerebellar development. These neurons are diverse, integrating information from the cerebellar cortex and relaying it to various brain regions. Employing various methodologies, we have characterized a specific subset of CN neurons that do not originate from the rhombic lip or ventricular zone of the cerebellar primordium. Embryos were collected at early stages of development and processed for immunohistochemistry (IHC), western blotting, in situ hybridization (ISH), embryonic culture, DiI labeling, and flow cytometry analysis (FCM). Our findings indicate that a subset of CN neurons expressing α-synuclein (SNCA), OTX2, MEIS2, and p75NTR (NGFR) are located in the rostroventral region of the NTZ. While CN neurons derived from the rhombic lip are positioned in the caudodorsal area of the NTZ in the cerebellar primordium. Utilizing Otx2-GFP and

Indexed as

Cerebellar NucleiNeuronsOtx Transcription FactorsAnimalsBasic Helix-Loop-Helix ProteinsFlow CytometryImmunohistochemistryMiceMice, KnockoutAtoh1 protein, mouseBasic Helix-Loop-Helix ProteinsOtx2 protein, mouseOtx Transcription FactorsAtoh1cerebellar nucleiMEIS2mouseneuroscienceOTX2SNCA

Identifiers

PMID39679919
PMCPMC11649241

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.