Evidence map›Paper›PMID 39679828›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Activatable Sulfur Dioxide Nanosonosensitizer Enables Precisely Controllable Sono-Gaseous Checkpoint Trimodal Therapy for Orthotopic Hepatocellular Carcinoma.

Jing Liang, Guangwen Cheng, Luping Qiu, Liyun Xue, Huning Xu, Xiaohui Qiao, Na Guo, Huijing Xiang, Yu Chen, Hong Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jing LiangDepartment of Ultrasound, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Guangwen ChengDepartment of Ultrasound, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Luping QiuDepartment of Ultrasound, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Liyun XueDepartment of Ultrasound, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Huning XuDepartment of Ultrasound, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xiaohui QiaoDepartment of Ultrasound, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Na GuoDepartment of Pathology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China.
Huijing XiangMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 2000444, China.
Yu ChenMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 2000444, China.ORCID https://orcid.org/0000-0002-8206-3325
Hong DingDepartment of Ultrasound, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Funding

Innovative research team of high-level local universities in ShanghaiKey Science and Technology Research and Development Projects of Jiangxi Province 20223BBH80014National Natural Science Foundation of China 3217139National Natural Science Foundation of China 82272017National Natural Science Fund for Young Scholars 82202185National Natural Science Fund for Young Scholars 82302217National Science Fund for Excellent Young Scholars T2322018Shanghai Rising-Star Program 22QA1403600Shanghai Science and Technology Development Fund 22Y11911500Shanghai Science and Technology Program 21010500100Shanghai Shuguang Program 21SG39
6 · The paper itself

Abstract

Immune checkpoint blockade (ICB) is combined with sonodynamic therapy (SDT) to increase response rates and enhance anticancer efficacy. However, the "always on" property of most sonosensitizers in reducing tumor microenvironment (TME) compromises the therapeutic outcome of sonoimmunotherapy and exacerbates adverse side effects. Precisely controllable strategies combining sulfur dioxide (SO

Indexed as

Carcinoma, HepatocellularImmunotherapyLiver NeoplasmsNanoparticlesSulfur DioxideUltrasonic TherapyAnimalsCell Line, TumorCombined Modality TherapyHumansImmune Checkpoint InhibitorsMiceTumor MicroenvironmentImmune Checkpoint InhibitorsSulfur Dioxidegas therapyimmunotherapynanomedicinenanosonosensitizersonodynamic therapy

Identifiers

PMID39679828
PMCPMC11791957

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.