SynthesisVeterinary surgery : VS2025
The association between gonadectomy and timing of gonadectomy, and the risk of canine cranial cruciate ligament disease: A systematic review and meta-analysis.
Synthesis in Veterinary surgery : VS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between gonadectomy and timing of gonadectomy, and the risk of canine cranial cruciate ligament disease: A systematic review and meta-analysis.Veterinary surgery : VS · 2025Pooled it
- Machine-learning prediction of postoperative complications after high tibial osteotomy for canine cranial cruciate ligament disease.Veterinary surgery : VS · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveTo determine if gonadectomy in dogs is associated with the risk of cranial cruciate ligament disease (CrCLD) and to quantify the magnitude of the association. STUDY
designSystematic review and meta-analysis. SAMPLE POPULATION: Comparative studies with gonadectomized and entire dogs, with CrCLD as an outcome measure.
methodsA systematic search of the primary and gray literature was performed. The effect size of the outcome measure was defined as the OR and 95% CI. Subgroup analysis was performed with sex, breed, and age at gonadectomy. A pooled OR (95% CI) was generated from meta-analysis of relevant studies. Certainty in the body of evidence was rated with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.
resultsThe literature search yielded 1398 results and 24 relevant studies were included for synthesis. Gonadectomized female (pooled OR = 2.293, 95% CI = 1.768-2.945) and male (pooled OR = 2.117, 95% CI = 1.665-2.691) dogs were both at increased odds of developing CrCLD in comparison with entire female and male dogs, respectively. Subgroup analysis showed that gonadectomy at 1 year or less was consistently associated with an increase in odds of developing CrCLD in both sexes. Overall certainty in the evidence was rated as moderate. All included studies were observational and no controlled trials were available.
conclusionIn data with moderate certainty, gonadectomy is associated with increased odds of developing CrCLD in both sexes, particularly in dogs gonadectomized at 1 year of age or less. CLINICAL SIGNIFICANCE: This study provides an estimate of the true effect size of gonadectomy on the odds of developing CrCLD, which may be useful for clinical decision making surrounding gonadectomy and the timing of gonadectomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.