ArticleMovement disorders : official journal of the Movement Disorder Society2025
All-Cause and Cause-Specific Mortality in Tourette Syndrome and Chronic Tic Disorder.
Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Efficacy and Safety of Ecopipam for Tourette Syndrome: A Phase 3 Randomized Clinical Trial.JAMA neurology · 2026Trial
- Tourette syndrome.Nature reviews. Disease primers · 2026Review
- Mortality in people with attention-deficit/hyperactivity disorder (ADHD): Examining how risk is embodied in a pooling of two prospective cohort studies.medRxiv : the preprint server for health sciences · 2026Article
- Pregnancy, Delivery, and Neonatal Outcomes in Women with Tourette Syndrome or Chronic Tic Disorder.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Epidemiology of Tourette Syndrome.Brain sciences · 2025Review
- The clinical features and initial pharmacotherapeutic options of children with Tic disorders.Frontiers in pediatrics · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundTourette syndrome (TS) and chronic tic disorder (CTD) may be associated with an increased risk of mortality, but specific causes of death are poorly understood.
objectivesIn this matched cohort and sibling cohort study, we estimated the risk of all-cause and cause-specific mortality in individuals with TS/CTD, compared with unaffected matched individuals and unaffected full siblings.
methodsWe identified all individuals diagnosed with TS/CTD in the Swedish National Patient Register who were living in the country between 1973 and 2020 and matched them (1:10) to individuals without TS/CTD from the general population. We also identified their siblings without TS/CTD. All-cause and cause-specific mortality outcomes, based on the International Classification of Diseases codes, were extracted from the Cause of Death Register. Covariates included sociodemographic variables and psychiatric disorders. Risks of mortality were estimated using Cox proportional hazards regression models.
resultsWe included 10,280 individuals with TS/CTD and 102,800 matched individuals without TS/CTD. In adjusted models, individuals with TS/CTD had an 86% increased hazard of all-cause mortality (hazard ratio: 1.86, 95% confidence interval: 1.65-2.11). The increased risk was observed for both natural (particularly nervous, digestive, and respiratory system diseases) and unnatural causes of death (including suicides and accidents). The sibling comparison showed similar results, indicating that the associations were unlikely to be explained by familial confounding.
conclusionsIndividuals with TS/CTD are at increased risk of death due to both natural and unnatural causes. As some of these deaths are potentially preventable, greater focus on the somatic health of individuals with TS/CTD is warranted. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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