Evidence map›Paper›PMID 39679695›Full record

Trial reportClinical pharmacology and therapeutics2025

Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.

Abdulsalam Aliyu, Neele Dellschaft, Caroline Hoad, Hannah Williams, Emily Gaudoin, Sarah Sulaiman, Colin Crooks, Penny Gowland, Alexia Aran, Robert Lange and 4 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical pharmacology and therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07569419 (A Randomised, Placebo-controlled Crossover Study Defining the Mode of Action of Linaclotide in Healthy Volunteers Using MRI), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07569419 early_phase1recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomised, Placebo-controlled Crossover Study Defining the Mode of Action of Linaclotide in Healthy Volunteers Using MRI

TypeinterventionalSponsorUniversity of NottinghamRan2026 to 2026Enrolled26ConditionsCystic Fibrosis (CF)ArmsLinaclotide 290 micrograms, Lactose placebo pill
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The mechanisms and management of fecal incontinence in geriatric neurological diseases.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Abdulsalam AliyuNottingham NIHR Research Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0002-7326-0917
Neele DellschaftSir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0001-5483-1684
Caroline HoadSir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0001-5483-1027
Hannah WilliamsSir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, UK.
Emily GaudoinSir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, UK.
Sarah SulaimanSchool of Medicine, University of Nottingham, Nottingham, UK.
Colin CrooksNottingham NIHR Research Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0002-6794-6621
Penny GowlandSir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0002-4900-4817
Alexia AranSanofi, Barcelona, Spain.ORCID 0009-0009-0454-6012
Robert LangeSanofi, Frankfurt am Main, Germany.ORCID 0000-0002-9500-1238
Beatrice Bois De FerSanofi, Neuilly-sur-Seine, France.
Maura CorsettiNottingham NIHR Research Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0003-2957-4684
Luca MarcianiNottingham NIHR Research Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0001-9092-4300
Robin SpillerNottingham NIHR Research Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0001-6371-4500

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo-controlled cross-over trials were performed, one using a single dose of Bisacodyl 5 mg while the second dosed daily for 3 consecutive days. Serial MRI was performed every 75 minutes. Primary endpoint: ascending colon water content as assessed by T1AC AUC

Indexed as

BisacodylConstipationLaxativesMagnetic Resonance ImagingAdultColonCross-Over StudiesDefecationDouble-Blind MethodFemaleGastrointestinal MotilityGastrointestinal TransitHumansMaleMiddle AgedYoung AdultBisacodylLaxatives

Identifiers

PMID39679695
PMCPMC11993282

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.