Evidence map›Paper›PMID 39679680›Full record

ArticlemBio2025

Stage-specific function of sphingolipid synthases in African trypanosomes.

Norton Heise, Carolina M Koeller, Mohamed Sharif, James D Bangs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Norton HeiseInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Carolina M KoellerInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0002-1919-7582
Mohamed SharifDepartment of Microbiology & Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
James D BangsDepartment of Microbiology & Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.ORCID 0000-0001-7903-6521

Funding

Secretory Protein Trafficking and Folding in African TrypanosomesR01AI035739 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BANGS, JAMES D. · 2000 to 2020
$6.6M
SECRETION AND PROTEIN TARGETING IN TRYPANOSOMA BRUCEIR29AI035739 · NIAID · UNIVERSITY OF WISCONSIN MADISON · PI BANGS, JAMES D. · 1995 to 1999
–
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) APQ1-FAPERJ E-26/211.479/2021Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) CAPES-PRINT 88887.695216/2022-00HHS | National Institutes of Health (NIH) AI35739NIAID NIH HHS R01 AI035739NIAID NIH HHS R29 AI035739UB | Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (JSMBS) na
6 · The paper itself

Abstract

The protozoan parasite IMPORTANCE: African trypanosomes are eukaryotic pathogens that cause human and veterinary African trypanosomaisis. Uniquely, they synthesize all three major phosphosphingolipid species using four distinct sphingolipid synthases (SLS). This work details the function of each SLS in both bloodstream and insect form parasites. Novel and unexpected sphingolipid dependences are found in each stage. These results are consistent with this metabolic pathway being a valid target for chemotherapeutic intervention.

Indexed as

Sphingosine N-AcyltransferaseTrypanosoma brucei bruceiAnimalsGlycosphingolipidsSphingolipidsSphingomyelinsTransferases (Other Substituted Phosphate Groups)GlycosphingolipidsinositolphosphorylceramideSphingolipidsSphingomyelinsSphingosine N-AcyltransferaseTransferases (Other Substituted Phosphate Groups)inositolphosphorylceramidesphingolipidsphingolipid synthasesphingomyelintrypanosome

Identifiers

PMID39679680
PMCPMC11796370

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.